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Noradrenergic excitation of astrocytes supports cognitive reserve.

作者信息

Zorec Robert, Verkhratsky Alexei

机构信息

Laboratory of Neuroendocrinology and Molecular Cell Physiology, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia (Zorec R, Verkhratsky A).

Celica Biomedical, Technology Park, Ljubljana, Slovenia (Zorec R, Verkhratsky A).

出版信息

Neural Regen Res. 2026 Apr 1;21(4):1546-1547. doi: 10.4103/NRR.NRR-D-24-01395. Epub 2025 Jan 29.

DOI:10.4103/NRR.NRR-D-24-01395
PMID:40587240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12407521/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7098/12407521/7e295c4635ef/NRR-21-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7098/12407521/7e295c4635ef/NRR-21-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7098/12407521/7e295c4635ef/NRR-21-1546-g001.jpg

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本文引用的文献

1
Adenosine signalling to astrocytes coordinates brain metabolism and function.腺苷向星形胶质细胞发出的信号协调大脑代谢与功能。
Nature. 2024 Aug;632(8023):139-146. doi: 10.1038/s41586-024-07611-w. Epub 2024 Jul 3.
2
Neuroglia in cognitive reserve.认知储备中的神经胶质细胞。
Mol Psychiatry. 2024 Dec;29(12):3962-3967. doi: 10.1038/s41380-024-02644-z. Epub 2024 Jul 2.
3
Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.
蓝斑、皮质和皮质下区域之间的微观结构关联受星形胶质细胞反应性的调节:一项 7T MRI 成人寿命研究。
Cereb Cortex. 2024 Jun 4;34(6). doi: 10.1093/cercor/bhae261.
4
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition.蓝斑核完整性的时空模式预测皮质tau 和认知。
Nat Aging. 2024 May;4(5):625-637. doi: 10.1038/s43587-024-00626-y. Epub 2024 Apr 25.
5
Astrocytes in human central nervous system diseases: a frontier for new therapies.人类中枢神经系统疾病中的星形胶质细胞:新疗法的前沿。
Signal Transduct Target Ther. 2023 Oct 13;8(1):396. doi: 10.1038/s41392-023-01628-9.
6
Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory.乙酰胆碱和去甲肾上腺素对海马体依赖的空间学习和记忆有不同的调节作用。
Brain Commun. 2022 Dec 22;5(1):fcac338. doi: 10.1093/braincomms/fcac338. eCollection 2023.
7
The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes.GPR27 的激活可增加 3T3 胚胎细胞和星形胶质细胞中的胞质 L-乳酸。
Cells. 2022 Mar 16;11(6):1009. doi: 10.3390/cells11061009.
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Exocytosis of large-diameter lysosomes mediates interferon γ-induced relocation of MHC class II molecules toward the surface of astrocytes.大直径溶酶体的胞吐作用介导了干扰素γ诱导的MHC II类分子向星形胶质细胞表面的重新定位。
Cell Mol Life Sci. 2020 Aug;77(16):3245-3264. doi: 10.1007/s00018-019-03350-8. Epub 2019 Oct 30.
9
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FEBS J. 2018 Oct;285(19):3645-3656. doi: 10.1111/febs.14456. Epub 2018 Apr 16.
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Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease.常染色体显性遗传性阿尔茨海默病中星形细胞增生和淀粉样蛋白PET的纵向变化差异
Brain. 2016 Mar;139(Pt 3):922-36. doi: 10.1093/brain/awv404. Epub 2016 Jan 26.