Ying Xiaoqi, Xu Jingyang, Yu Qintao, Wang Xinru, Lan Songsen, Hu Liwan, Zhang Ying, Han Dexiong
The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Medicine (Baltimore). 2025 Jun 27;104(26):e42166. doi: 10.1097/MD.0000000000042166.
Since an increasing number of studies on glymphatic system (GS) have been published, this study aimed to evaluate the research trends, hotspots, and frontiers of GS in cognition. Publications from the Web of Science Core Collection database from January 1, 2009 to December 31, 2023 were screened. The analysis of annual publications, countries/regions, institutions, journals, authors, co-cited journals, co-cited authors, and keywords was conducted using CiteSpace and VOSviewer, the hotspots and major findings were summarized. In addition, ArcGIS software was used to display the number of publications by countries/regions. Six hundred twenty-five publications were included. Overall, the number of publications has been increasing steadily, these were published in 59 countries/regions and 149 institutions. Of these, American institutions had the highest number, and their international influence also ranked first. The journal "Neurology" published the most publications and was considered the most co-cited journal. The article entitled "The glymphatic pathway in neurological disorders" in Lancet neurology had the most citations. The keywords with the highest number of occurrences were "Alzheimer disease" and "small vessel disease," which were regarded as research hotspots. Among 19 emergent terms, "Virchow robin spaces," "vascular dementia," and "autosomal dominant arteriopathy" were the first, and "white matter lesions" were the strongest. This bibliometric analysis reveals the rapid growth and evolving landscape of research on the GS in cognitive function. However, there remain significant knowledge gaps and methodological challenges that must be addressed to fully elucidate the mechanisms and implications of GS in cognitive impairment and neurodegeneration.
由于关于脑淋巴系统（GS）的研究越来越多，本研究旨在评估GS在认知方面的研究趋势、热点和前沿。筛选了2009年1月1日至2023年12月31日期间来自科学引文索引核心合集数据库的出版物。使用CiteSpace和VOSviewer对年度出版物、国家/地区、机构、期刊、作者、共被引期刊、共被引作者和关键词进行分析，总结热点和主要发现。此外，使用ArcGIS软件展示国家/地区的出版物数量。共纳入625篇出版物。总体而言，出版物数量一直在稳步增加，这些出版物发表在59个国家/地区和149个机构。其中，美国机构的数量最多，其国际影响力也排名第一。《神经病学》杂志发表的出版物最多，被认为是共被引最多的期刊。《柳叶刀·神经病学》上题为《神经疾病中的脑淋巴途径》的文章被引次数最多。出现次数最多的关键词是“阿尔茨海默病”和“小血管疾病”，它们被视为研究热点。在19个新兴术语中，“维氏间隙”“血管性痴呆”和“常染色体显性遗传性动脉病”排名第一，“白质病变”的影响力最强。这项文献计量分析揭示了GS在认知功能研究方面的快速增长和不断演变的格局。然而，仍然存在重大的知识空白和方法学挑战，必须加以解决，以充分阐明GS在认知障碍和神经退行性变中的机制和影响。
