Milner J D, Wurtman R J
Neurosci Lett. 1985 Aug 30;59(2):215-20. doi: 10.1016/0304-3940(85)90202-2.
Direct evidence that precursor levels can affect catecholamine release from brain cells has not previously been presented. We observe a dose-dependent relationship between the tyrosine (Tyr) concentration of the superfusing medium and the amount of dopamine (DA) released from rat striatum by trains of electrical pulses. In the absence of exogenous tyrosine, tissue Tyr and DA levels are reduced following stimulation. These findings suggest that DA release from striatal neurons may not be sustained if fluctuations occur in the supply of Tyr to the brain.
此前尚未有关于前体水平可影响脑细胞儿茶酚胺释放的直接证据。我们观察到，灌注液中酪氨酸（Tyr）浓度与大鼠纹状体经电脉冲串刺激后释放的多巴胺（DA）量之间存在剂量依赖性关系。在无外源性酪氨酸的情况下，刺激后组织中的酪氨酸和多巴胺水平会降低。这些发现表明，如果大脑中酪氨酸供应出现波动，纹状体神经元释放多巴胺可能无法持续。
