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用于心脏健康评估的石墨烯衍生物增强多分析物识别的最新进展

Recent Progress in Multi-Analytes Recognition Reinforced by Graphene Derivatives for Cardio Health Assessments.

作者信息

Suhaimi M A H, Taniselass S, Md Arshad M K, Gopinath Subash C B, Fathil M F M, Ramli M M, Hasan I H

机构信息

Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), Kangar, Malaysia.

Faculty of Electronic Engineering & Technology, Universiti Malaysia Perlis (UniMAP), Arau, Malaysia.

出版信息

Crit Rev Anal Chem. 2025 Jun 30:1-14. doi: 10.1080/10408347.2025.2525201.

Abstract

The escalating prevalence of cardiovascular diseases globally call for a low-cost monitoring technology for an immediate intervene and diagnoses. Advance multiplexed biosensors reinforced by graphene derivatives marks a significant progression in the field of cardiovascular health assessments. The graphene derived biosensors are designed specifically for fast detection of cardiac biomarkers with high precision to evaluate cardiovascular health. The graphene biocompatibility and fast signal transduction electronic properties provide an ideal foundation for the multiplexed technology. Despite the substantial potential of this multiplexed technologies, there remains a pressing need for further research and development to fully harness their capabilities in clinical environments. This study underscores the critical role of these biosensors in point of care applications and reviews the current landscape of research, highlighting significant progress made in graphene-based transduction and the recent trends in graphene production which give impact on biosensors performance. Key components are discussed include the assessment of vital cardiac biomarkers and the evolution of multiplex biosensing strategies that utilizes graphene nanomaterials. In summary, this review provides a comprehensive overview of the latest advancements in multi-analyte detection for cardiac healthcare. It outlines the key challenges encountered while proposing potential strategies to improve the effectiveness of multiplex biosensing platforms, thereby supporting the advancement of cardiac diagnostics. The potential of multiplexed biosensing technology leads to enhance diagnostic capabilities while reducing healthcare costs represents a significant advancement in cardiovascular healthcare, particularly for point-of-care applications.

摘要

全球心血管疾病患病率不断攀升,需要一种低成本监测技术以便立即进行干预和诊断。由石墨烯衍生物强化的先进多重生物传感器标志着心血管健康评估领域的重大进展。石墨烯衍生的生物传感器专为快速、高精度检测心脏生物标志物以评估心血管健康而设计。石墨烯的生物相容性和快速信号转导电子特性为多重技术提供了理想基础。尽管这种多重技术具有巨大潜力,但仍迫切需要进一步研发,以在临床环境中充分发挥其能力。本研究强调了这些生物传感器在即时护理应用中的关键作用,并回顾了当前的研究现状,突出了基于石墨烯的转导方面取得的重大进展以及影响生物传感器性能的石墨烯生产最新趋势。讨论的关键组件包括重要心脏生物标志物的评估以及利用石墨烯纳米材料的多重生物传感策略的演变。总之,本综述全面概述了心脏医疗保健中多分析物检测的最新进展。它概述了遇到的关键挑战,同时提出了提高多重生物传感平台有效性的潜在策略,从而支持心脏诊断的进步。多重生物传感技术在提高诊断能力的同时降低医疗成本的潜力代表了心血管医疗保健领域的重大进展,特别是对于即时护理应用。

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