文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

灭活分枝杆菌疫苗雾化吸入：一种预防和治疗呼吸道疾病的有效疗法？

Inactivated Mycobacterial Vaccine Nebulized Inhalation: A Effective Therapy for the Prevention and Treatment of Respiratory Diseases?

作者信息

Jiang Xiaohong, Sun Qixiang, Huang Yujia, Deng Yuetian, Li Chaoqian

机构信息

Department of Geriatric Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.

出版信息

Clin Respir J. 2025;19(7):e70101. doi: 10.1111/crj.70101.

DOI:10.1111/crj.70101
PMID:40592802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12213138/
Abstract

Nebulized inhalation therapy is an important method in the prevention and treatment of respiratory diseases, and inactivated mycobacterial vaccine nebulized inhalation has received a wide attention recently, but the roles and mechanisms are still not fully understood. A literature search showed there is a strong scientific rationale and evidence that nebulized inhalation of inactivated mycobacterial vaccine is effective in the prevention and treatment of respiratory diseases. Clinically available mycobacterial vaccines include Mycobacterium phlei (M. phlei), BCG, and Mycobacterium vaccae (M. vaccae). Nebulized inhalation of inactivated mycobacterial vaccine, especially M. vaccae, has been used in the prevention and treatment of respiratory diseases, such as asthma, respiratory syncytial virus (RSV), coronavirus disease 2019 (COVID-19), and sepsis. It acts on the respiratory tract directly, thus stimulating the body to produce an immune response, enhance respiratory immunity, and achieve prevention and treatment effects. Nebulized inhalation of inactivated mycobacterial vaccine will be an effective therapy in the prevention and treatment of respiratory diseases.

摘要

雾化吸入疗法是防治呼吸道疾病的重要方法，近年来灭活分枝杆菌疫苗雾化吸入受到广泛关注，但其作用及机制仍未完全明确。文献检索表明，有充分的科学依据和证据显示，雾化吸入灭活分枝杆菌疫苗对防治呼吸道疾病有效。临床上可用的分枝杆菌疫苗包括草分枝杆菌、卡介苗和母牛分枝杆菌。雾化吸入灭活分枝杆菌疫苗，尤其是母牛分枝杆菌，已用于防治呼吸道疾病，如哮喘、呼吸道合胞病毒（RSV）、2019冠状病毒病（COVID-19）和脓毒症。它直接作用于呼吸道，从而刺激机体产生免疫反应，增强呼吸道免疫力，达到防治效果。雾化吸入灭活分枝杆菌疫苗将成为防治呼吸道疾病的有效疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f0/12213138/2f5960904365/CRJ-19-e70101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f0/12213138/2f5960904365/CRJ-19-e70101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f0/12213138/2f5960904365/CRJ-19-e70101-g002.jpg

相似文献

[1]
Inactivated Mycobacterial Vaccine Nebulized Inhalation: A Effective Therapy for the Prevention and Treatment of Respiratory Diseases?

Clin Respir J. 2025

[2]
Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature.

Health Technol Assess. 2001

[3]
Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over.

Health Technol Assess. 2008-5

[4]
Vaccines for preventing influenza in healthy children.

Cochrane Database Syst Rev. 2018-2-1

[5]
Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis.

Cochrane Database Syst Rev. 2023-2-3

[6]
Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years.

Health Technol Assess. 2008-5

[7]
Influenza vaccine for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev. 2018-6-26

[8]
Adverse effects of beta-agonists: are they clinically relevant?

Am J Respir Med. 2003

[9]
Nebulized racemic epinephrine for extubation of newborn infants.

Cochrane Database Syst Rev. 2002

[10]
Vaccines for preventing influenza in healthy children.

Cochrane Database Syst Rev. 2012-8-15

本文引用的文献

[1]
Nebuliser therapy in critical care: The past, present and future.

J Intensive Care Soc. 2024-2

[2]
Mycobacterium vaccae attenuates airway inflammation by inhibiting autophagy and activating PI3K/Akt signaling pathway in OVA-induced allergic airway inflammation mouse model.

Mol Immunol. 2024-9

[3]
Therapeutic vaccines for advanced non-small cell lung cancer.

Cochrane Database Syst Rev. 2024-3-12

[4]
A perspective current and past modes of inhalation therapy.

Microb Biotechnol. 2024-2

[5]
Mycobacterium vaccae alleviates allergic airway inflammation and airway hyper-responsiveness in asthmatic mice by altering intestinal microbiota.

Immunology. 2024-4

[6]
Prevention and Treatment Strategies for Respiratory Syncytial Virus (RSV).

Pathogens. 2023-1-17

[7]
BCG-induced trained immunity: history, mechanisms and potential applications.

J Transl Med. 2023-2-10

[8]
Mycobacterium Vaccae Regulate γδT17 and γδTreg Cells in Mice Asthmatic Lung.

Iran J Immunol. 2022-9

[9]
Respiratory syncytial virus, recurrent wheeze and asthma: A narrative review of pathophysiology, prevention and future directions.

J Paediatr Child Health. 2022-10

[10]
Genomic, Metabolic, and Immunological Characterization of GMP-Grade Mycobacterium phlei.

Microbiol Spectr. 2022-8-31

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索