Department of Biochemistry and Molecular Biology II, Pharmacy School, University of Granada, Granada, Spain.
Pharmacy Services, A.S. Hospital de Poniente de Almería, Almería, Spain.
Microb Biotechnol. 2024 Feb;17(2):e14419. doi: 10.1111/1751-7915.14419.
Inhalation is the preferred route of delivery for anti-asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with minimal systemic exposure, thereby reducing the risk of adverse effects. Therefore, the current brief covers an interesting collection of inhaler action modes, shedding light on their molecular mechanisms and clinical applications for anti-asthma, COPD and antibacterial inhalation therapy. Hence, not only enriches our understanding of inhalation therapy molecular intricacies but also provides a comprehensive overview of the evolving landscape in clinical and antibacterial inhalation therapy. In doing so, it underscores the pivotal role of microbiology and biotechnology in advancing therapeutic approaches that harness the power of inhalation.
吸入是治疗哮喘和慢性阻塞性肺疾病（COPD）药物的首选给药途径。该途径在这些疾病和其他疾病中的应用已证明具有疗效，它具有起效迅速的特点，并且全身暴露量最小，从而降低了不良反应的风险。因此，本简要综述涵盖了一系列有趣的吸入器作用模式，揭示了它们在哮喘、COPD 和抗菌吸入治疗中的分子机制和临床应用。因此，不仅丰富了我们对吸入治疗分子复杂性的理解，还全面概述了临床和抗菌吸入治疗的发展格局。这样做强调了微生物学和生物技术在推进利用吸入力量的治疗方法方面的关键作用。
