Li Xin, Han Qingquan, Li Xianbao, Li Rui, Wang Anhe, Liang Sen, Sang Yutao, Li Jieling, Tian Yajie, Yang Yang, Li Qi, Bai Shuo, Li Junbai
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Nat Commun. 2025 Jul 1;16(1):6044. doi: 10.1038/s41467-025-61007-6.
Peptide-based materials offer unique advantages for constructing supramolecular chiral systems due to their bioactivity and intrinsic chirality. However, precise control over the expression, transfer, and amplification of chirality from the molecular to supramolecular level remains a significant challenge in developing high-performance chiral materials. In this study, we demonstrate that achiral anions regulate hydrogen bonding interactions in dipeptide assembly, leading to the formation of chiral microrolls composed of two-dimensional nanosheets. These microrolls exhibit pH-dependent chiroptical switching and intense circularly polarized luminescence with a dissymmetry factor (|g|) of 0.062. Furthermore, the chiral ultraviolet emission from these microrolls enables enantioselective polymerization of diacetylene, offering potential applications in chiral catalysis. These findings enhance our understanding of chirality modulation in biomolecular assemblies and provide a pathway toward the development of high-performance chiral biomaterials.
基于肽的材料因其生物活性和固有手性，在构建超分子手性体系方面具有独特优势。然而，在从分子水平到超分子水平精确控制手性的表达、转移和放大，仍是开发高性能手性材料的一项重大挑战。在本研究中，我们证明了非手性阴离子调节二肽组装中的氢键相互作用，导致由二维纳米片组成的手性微卷形成。这些微卷表现出pH依赖的手性光学开关和不对称因子（|g|）为0.062的强烈圆偏振发光。此外，这些微卷的手性紫外发射能够实现双乙炔的对映选择性聚合，在手性催化方面具有潜在应用。这些发现加深了我们对生物分子组装中手性调制的理解，并为开发高性能手性生物材料提供了一条途径。
