Orman Mujgan, Sirolu Sabri, Seker Mustafa Ege, Alis Deniz, Kartal Mustafa Said, Basar Yeliz, Denizoglu Nurper, Kurtcan Serpil, Arslan Aydan, Oksuz Ilkay, Karaarslan Ercan
Department of Radiology, Acibadem Healthcare Group, Istanbul, 34457, Turkey.
Department of Radiology, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, 34396, Turkey.
Sci Rep. 2025 Jul 2;15(1):22865. doi: 10.1038/s41598-025-02973-1.
The Prostate Imaging Quality (PI-QUAL) V2 is a simplified update of PI-QUAL V1 for assessing image quality in multiparametric prostate MRI (mpMRI), aimed at improving clinical use and reproducibility. This study evaluated inter-reader agreement of PI-QUAL V2 among basic prostate readers using multicenter mpMRI data and compared it to PI-QUAL V1. Five readers assessed T2-weighted, DWI (including ADC maps), and DCE images from 274 men (median age: 71 years, IQR: 60-78) across five centers. Inter-reader agreement was measured using weighted Gwet's AC1 coefficients and compared using bootstrapped confidence intervals. For PI-QUAL V1, coefficients ranged from 0.659 to 0.855, indicating substantial-to-almost perfect agreement. For PI-QUAL V2, coefficients ranged from 0.821 to 0.897, showing almost perfect agreement. All 10 pairwise comparisons achieved almost perfect agreement for PI-QUAL V2, compared to only 3 of 10 for V1. Additionally, three comparisons showed non-overlapping confidence intervals, indicating statistically significant improvements with V2. PI-QUAL V2 demonstrated consistently higher inter-reader agreement than V1, with basic prostate readers achieving almost perfect agreement across multicenter mpMRI data. These findings highlight the improved reliability and clinical applicability of PI-QUAL V2.
前列腺成像质量（PI-QUAL）V2是PI-QUAL V1的简化升级版，用于评估多参数前列腺MRI（mpMRI）中的图像质量，旨在改善临床应用和可重复性。本研究使用多中心mpMRI数据评估了基础前列腺阅片者之间PI-QUAL V2的阅片者间一致性，并将其与PI-QUAL V1进行比较。五名阅片者对来自五个中心的274名男性（中位年龄：71岁，四分位间距：60 - 78岁）的T2加权、DWI（包括ADC图）和DCE图像进行了评估。使用加权Gwet's AC1系数测量阅片者间一致性，并使用自助置信区间进行比较。对于PI-QUAL V1，系数范围为0.659至0.855，表明一致性为实质性至几乎完美。对于PI-QUAL V2，系数范围为0.821至0.897，显示几乎完美的一致性。PI-QUAL V2的所有10对比较均达到几乎完美的一致性，而PI-QUAL V1的10对比较中只有3对达到。此外，三项比较显示置信区间不重叠，表明V2有统计学上的显著改善。PI-QUAL V2在阅片者间一致性方面始终高于V1，基础前列腺阅片者对多中心mpMRI数据达到了几乎完美的一致性。这些发现突出了PI-QUAL V2提高的可靠性和临床适用性。
