O'Brien C J, Harris J P, May J
Br J Plast Surg. 1986 Jan;39(1):103-8. doi: 10.1016/0007-1226(86)90012-3.
Previous studies of 1 mm internal diameter polytetrafluoroethylene (PTFE) have investigated short graft lengths. The aim of this experiment was to assess a longer, clinically useful graft. Femoro-femoral crossover grafts 6 cm long were implanted into 20 rats and, after an initial observation period of 1 hour, were followed up for four weeks. Ten grafts failed within the first hour post-operatively, one was occluded at 2 weeks and nine were patent at 4 weeks (45% patency). Technical errors causing stasis within the prosthesis led to the early failures. When stasis was avoided patency was good and did not appear to be dependent upon development of a cellular lining within the graft.
先前对内径1毫米聚四氟乙烯（PTFE）的研究调查的是较短的移植物长度。本实验的目的是评估更长的、具有临床实用性的移植物。将6厘米长的股-股交叉移植物植入20只大鼠体内，在最初1小时的观察期后，随访四周。10个移植物在术后第一小时内失败，1个在2周时闭塞，9个在4周时通畅（通畅率45%）。假体内部导致血流淤滞的技术失误导致了早期失败。当避免血流淤滞时，通畅情况良好，且似乎不依赖于移植物内细胞内衬的形成。
