达尼丁太平洋神经影像衰老时钟（DunedinPACNI）通过单一脑图像估计衰老的纵向进程，以追踪健康与疾病状况。
DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease.
作者信息
Whitman Ethan T, Elliott Maxwell L, Knodt Annchen R, Abraham Wickliffe C, Anderson Tim J, Cutfield Nicholas J, Hogan Sean, Ireland David, Melzer Tracy R, Ramrakha Sandhya, Sugden Karen, Theodore Reremoana, Williams Benjamin S, Caspi Avshalom, Moffitt Terrie E, Hariri Ahmad R
机构信息
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA, USA.
出版信息
Nat Aging. 2025 Jul 1. doi: 10.1038/s43587-025-00897-z.
To understand how aging affects functional decline and increases disease risk, it is necessary to develop measures of how fast a person is aging. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain magnetic resonance imaging, that is, the Dunedin Pace of Aging Calculated from NeuroImaging (DunedinPACNI). Exporting this measure to the Alzheimer's Disease Neuroimaging Initiative, UK Biobank and BrainLat datasets revealed that faster DunedinPACNI predicted cognitive impairment, accelerated brain atrophy and conversion to diagnosed dementia. Faster DunedinPACNI also predicted physical frailty, poor health, future chronic diseases and mortality in older adults. When compared to brain age gap, DunedinPACNI was similarly or more strongly related to clinical outcomes. DunedinPACNI is a next-generation brain magnetic resonance imaging biomarker that can help researchers explore aging effects on health outcomes and evaluate the effectiveness of antiaging strategies.
为了解衰老如何影响功能衰退并增加疾病风险，有必要开发衡量一个人衰老速度的指标。利用达尼丁研究的数据，我们引入了一种准确可靠的纵向衰老速率指标，该指标源自横断面脑磁共振成像，即通过神经成像计算得出的达尼丁衰老速度（DunedinPACNI）。将该指标应用于阿尔茨海默病神经成像计划、英国生物银行和BrainLat数据集后发现，DunedinPACNI越快，预示着认知障碍、脑萎缩加速以及向确诊痴呆症的转化。DunedinPACNI越快还预示着老年人身体虚弱、健康状况不佳、未来患慢性病以及死亡。与脑年龄差距相比，DunedinPACNI与临床结果的相关性相似或更强。DunedinPACNI是一种下一代脑磁共振成像生物标志物，可帮助研究人员探索衰老对健康结果的影响，并评估抗衰老策略的有效性。
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