纳布西莫尔口腔黏膜喷雾剂治疗慢性移植物抗宿主病患者：对硬皮病样特征和难治性肌肉痉挛的影响 - Suppr

Nabiximols oromucosal spray in patients with chronic graft-versus-host disease: effects on sclerodermatous features and refractory muscle cramps.

作者信息

Gil-Manso Rodrigo, Hidalgo Calleja Cristina, Puebla Tornero Laura, Cabero-Martínez Almudena, García-Bacelar Ana, Martín López Ana África, Cabrero Mónica, Baile Mónica, Pérez-López Estefanía, Avendaño Pita Alejandro, Vázquez López Lourdes, Alonso Rodríguez Jennifer, Gilabert Gutiérrez María Del Carmen, Sánchez-Guijo Fermín, López-Corral Lucía

机构信息

Hematology Department, Complejo Asistencial Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Centro de Investigación del Cáncer-IBMCC, CIBERONC, Salamanca, Spain.

Reumatology Department, Complejo Asistencial Universitario de Salamanca-IBSAL, Salamanca, Spain.

出版信息

Bone Marrow Transplant. 2025 Jul 1. doi: 10.1038/s41409-025-02665-4.

DOI:10.1038/s41409-025-02665-4

PMID:40595356

Abstract

摘要

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Nabiximols oromucosal spray in patients with chronic graft-versus-host disease: effects on sclerodermatous features and refractory muscle cramps.纳布西莫尔口腔黏膜喷雾剂治疗慢性移植物抗宿主病患者：对硬皮病样特征和难治性肌肉痉挛的影响

Bone Marrow Transplant. 2025 Jul 1. doi: 10.1038/s41409-025-02665-4.

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Mult Scler Relat Disord. 2022 Dec;68:104173. doi: 10.1016/j.msard.2022.104173. Epub 2022 Sep 14.

Patient-reported benefits from nabiximols treatment in multiple sclerosis-related spasticity exceed conventional measures.患者报告纳比西莫司治疗多发性硬化相关痉挛的益处超过传统措施。

Neurodegener Dis Manag. 2024 Feb;14(1):11-20. doi: 10.2217/nmt-2023-0040. Epub 2024 Feb 6.

The effects of nabiximols (Sativex®) on spasticity and non-motor symptoms in chronic spinal cord injury (SCI): a longitudinal prospective study.纳布西莫尔（Sativex®）对慢性脊髓损伤（SCI）患者痉挛及非运动症状的影响：一项纵向前瞻性研究。

Spinal Cord Ser Cases. 2025 Jul 17;11(1):19. doi: 10.1038/s41394-025-00712-2.

Chronic Graft-versus-Host Disease-Associated Muscle Cramps: Severity and Response to Immunomodulatory Therapies.慢性移植物抗宿主病相关肌肉痉挛：严重程度及对免疫调节治疗的反应

Transplant Cell Ther. 2024 Mar;30(3):338.e1-338.e6. doi: 10.1016/j.jtct.2023.12.674. Epub 2024 Jan 3.

The effect of tetrahydrocannabinol:cannabidiol oromucosal spray on cognition: a systematic review.四氢大麻酚：大麻二酚口腔黏膜喷雾剂对认知的影响：一项系统评价

Eur J Clin Pharmacol. 2023 Mar;79(3):371-381. doi: 10.1007/s00228-023-03454-y. Epub 2023 Jan 26.

Usability of an application device for nabiximols oromucosal spray in patients with upper limb impaired multiple sclerosis.一种用于上肢运动障碍多发性硬化症患者的纳比昔单抗口腔喷雾剂的应用设备的可用性。

Neurodegener Dis Manag. 2022 Aug;12(4):195-201. doi: 10.2217/nmt-2022-0014. Epub 2022 Jun 16.

A Review of Scientific Evidence for THC:CBD Oromucosal Spray (Nabiximols) in the Management of Chronic Pain.四氢大麻酚：大麻二酚口腔黏膜喷雾剂（纳布西莫尔）用于慢性疼痛管理的科学证据综述

J Pain Res. 2020 Feb 14;13:399-410. doi: 10.2147/JPR.S240011. eCollection 2020.

Safety and tolerability of nabiximols oromucosal spray: a review of real-world experience in observational studies, registries, and case reports.纳布西莫尔口腔黏膜喷雾剂的安全性和耐受性：观察性研究、登记处及病例报告中的真实世界经验综述

Expert Rev Neurother. 2021 May;21(5):547-558. doi: 10.1080/14737175.2021.1904896. Epub 2021 Mar 30.

Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis.大麻和大麻素治疗多发性硬化症患者的症状。

Cochrane Database Syst Rev. 2022 May 5;5(5):CD013444. doi: 10.1002/14651858.CD013444.pub2.

本文引用的文献

Updates in chronic graft-versus-host disease management.慢性移植物抗宿主病管理的新进展。

Am J Hematol. 2023 Oct;98(10):1637-1644. doi: 10.1002/ajh.27040. Epub 2023 Jul 22.

Signaling through the type 2 cannabinoid receptor regulates the severity of acute and chronic graft-versus-host disease.通过 2 型大麻素受体信号转导调节急性和慢性移植物抗宿主病的严重程度。

Blood. 2021 Mar 4;137(9):1241-1255. doi: 10.1182/blood.2020004871.

Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation.大麻素可减轻炎症，但会抑制骨髓移植小鼠模型中的淋巴细胞恢复。

Int J Mol Sci. 2019 Feb 4;20(3):668. doi: 10.3390/ijms20030668.

Efficacy and safety of cannabinoid oromucosal spray for multiple sclerosis spasticity.大麻素口腔黏膜喷雾剂治疗多发性硬化痉挛的疗效与安全性。

J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):944-51. doi: 10.1136/jnnp-2015-312591. Epub 2016 May 9.

Cannabinoid CB₂ receptors are involved in the regulation of fibrogenesis during skin wound repair in mice.大麻素CB₂受体参与小鼠皮肤伤口修复过程中纤维生成的调节。

Mol Med Rep. 2016 Apr;13(4):3441-50. doi: 10.3892/mmr.2016.4961. Epub 2016 Mar 2.

Predictors of survival, nonrelapse mortality, and failure-free survival in patients treated for chronic graft-versus-host disease.接受慢性移植物抗宿主病治疗患者的生存、无复发死亡率和无失败生存的预测因素。

Blood. 2016 Jan 7;127(1):160-6. doi: 10.1182/blood-2015-08-662874. Epub 2015 Nov 2.

Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report.慢性移植物抗宿主病治疗反应的评估。美国国立卫生研究院慢性移植物抗宿主病临床试验标准共识发展项目：IV。2014年反应标准工作组报告。

Biol Blood Marrow Transplant. 2015 Jun;21(6):984-99. doi: 10.1016/j.bbmt.2015.02.025. Epub 2015 Mar 19.

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.美国国立卫生研究院慢性移植物抗宿主病临床试验标准共识发展项目：I. 2014年诊断与分期工作组报告

Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1. doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.

Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.异基因造血干细胞移植和移植物抗宿主病患者的肌肉痉挛和神经病变。

PLoS One. 2012;7(9):e44922. doi: 10.1371/journal.pone.0044922. Epub 2012 Sep 17.

Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology.评估：肌肉痉挛的对症治疗（基于证据的综述）：美国神经病学学会治疗学和技术评估小组委员会的报告。

Neurology. 2010 Feb 23;74(8):691-6. doi: 10.1212/WNL.0b013e3181d0ccca.

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Nabiximols oromucosal spray in patients with chronic graft-versus-host disease: effects on sclerodermatous features and refractory muscle cramps.

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