Kitamura J, Mori H, Sugie S, Kawai K
Res Commun Chem Pathol Pharmacol. 1985 Sep;49(3):415-22.
Mutagenicity and genotoxicity of antihypertensive drugs, ecarazine, budralazine, benzerazide, and carbidopa were compared with those of hydralazine whose genetic toxicity and carcinogenicity were well established. Ecarazine and budralazine as well as hydralazine showed apparent mutagenicity in Salmonella/microsome test using a strain TA 100 and weak mutagenicity in strains TA 97 and 2637. Benzerazide and carbidopa showed merely weak mutagenicity in TA 100. None of tested drugs except hydralazine exerted any positive result in hepatocyte primary culture (HPC)/DNA repair test, indicating no genotoxic activity of these hydrazine drugs.
将抗高血压药物依卡嗪、布屈嗪、苄醋嗪和卡比多巴的诱变性和遗传毒性与肼屈嗪进行了比较，后者的遗传毒性和致癌性已得到充分证实。依卡嗪、布屈嗪以及肼屈嗪在使用TA 100菌株的沙门氏菌/微粒体试验中表现出明显的诱变性，在TA 97和2637菌株中表现出弱诱变性。苄醋嗪和卡比多巴在TA 100中仅表现出弱诱变性。除肼屈嗪外，其他受试药物在肝细胞原代培养（HPC）/DNA修复试验中均未产生任何阳性结果，表明这些肼类药物无遗传毒性活性。
