Azimi Ali, Attar Alireza, Meshksar Aidin, Razmi Hooman, Jalalpour Mohammad Hassan, Fathian Amirmohammad, Yarmohammadi Adele
Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
UC San Diego Shiley Eye Institute, San Diego, USA.
BMC Res Notes. 2025 Jul 1;18(1):256. doi: 10.1186/s13104-025-07313-0.
To evaluate the impact of Ahmed glaucoma valve (AGV) implantation on ocular biometric and corneal biomechanical parameters in patients with neovascular glaucoma (NVG), with the goal of understanding how these changes influence intraocular pressure (IOP) control, surgical outcomes, and long-term prognosis.
Eighteen NVG patients (mean age: 57.44 ± 10.33 years) underwent AGV implantation. A significant reduction in IOP was observed, from 36.65 ± 12.3 mmHg preoperatively to 15.5 ± 2.64 mmHg postoperatively (p < 0.001). Axial length decreased from 23.42 ± 0.76 mm to 23.21 ± 0.76 mm (p < 0.001), while anterior chamber depth increased significantly (p = 0.037). Both corneal keratometry and central corneal thickness showed significant postoperative decreases (p < 0.001). Corneal biomechanical parameters such as peak distance and deformation amplitude increased significantly (p = 0.004 and p = 0.001, respectively), whereas no significant changes were noted in applanation lengths and velocities (p > 0.05). These findings suggest that AGV implantation leads to substantial alterations in ocular structure and biomechanics, which may contribute to improved clinical outcomes in NVG management.
评估 Ahmed 青光眼引流阀（AGV）植入术对新生血管性青光眼（NVG）患者眼部生物测量参数和角膜生物力学参数的影响，旨在了解这些变化如何影响眼压（IOP）控制、手术效果及长期预后。
18 例 NVG 患者（平均年龄：57.44 ± 10.33 岁）接受了 AGV 植入术。观察到眼压显著降低，从术前的 36.65 ± 12.3 mmHg 降至术后的 15.5 ± 2.64 mmHg（p < 0.001）。眼轴长度从 23.42 ± 0.76 mm 降至 23.21 ± 0.76 mm（p < 0.001），而前房深度显著增加（p = 0.037）。角膜曲率和中央角膜厚度术后均显著降低（p < 0.001）。角膜生物力学参数如峰值距离和变形幅度显著增加（分别为 p = 0.004 和 p = 0.001），而压平长度和速度无显著变化（p > 0.05）。这些发现表明，AGV 植入术导致眼部结构和生物力学发生实质性改变，这可能有助于改善 NVG 治疗的临床效果。
