精神健康障碍患者的长期新冠症状：一项范围综述

Long COVID in people with mental health disorders: a scoping review.

作者信息

Münte Catharina, Glattacker Manuela, Müller Saskia, Zülke Andrea E, Heinze Martin, Riedel-Heller Steffi G, Pieper Dawid, Jacke Christian, Deckert Stefanie, Neumann Anne

机构信息

Institute for General Practice and Palliative Care, Hannover Medical School, Hannover, Germany.

Faculty of Health Sciences Brandenburg, Brandenburg Medical School (Theodor Fontane), Institute for Health Services and Health System Research, Rüdersdorf, Germany.

出版信息

BMC Psychiatry. 2025 Jul 1;25(1):669. doi: 10.1186/s12888-025-06935-9.

DOI:10.1186/s12888-025-06935-9

PMID:40597822

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12219037/

Abstract

BACKGROUND

Long COVID, Post COVID Syndrome or PASC (post-acute sequelae of COVID-19), according to the World Health Organization (WHO), is defined as the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. The term Long COVID will be used throughout this review. Little is known about individuals with pre-existing mental health conditions experiencing Long COVID. This scoping review aims to provide an overview of these individuals, focusing on: 1) the course of mental disorders, 2) care needs, 3) utilization of healthcare services, and 4) psychosocial aspects, as outlined by the International Classification of Functioning (ICF).

METHODS

This review followed the JBI (Joanna Briggs Institute) methodology for scoping reviews and the PRISMA extension for scoping reviews. We included reports focusing on individuals with at least one pre-existing mental health diagnosis and Long COVID. Full-text reports in English or German were included, with no geographical limitations. Literature searches were conducted in PubMed, Embase, and PsycINFO on November 1, 2023, for records published between January 2020 and October 2023. Six reviewers participated in the screening process in pairs, independently conducting study selection and data extraction. Conflicts were resolved by consensus. Citation tracking was performed, and data were summarized narratively in tables.

RESULTS

From 4256 initial hits and citation tracking, 8 reports were included. The studies were heterogeneous, including chart reviews, case reports, cross-sectional, and longitudinal studies. Evidence on the impact of Long COVID on pre-existing mental health conditions was inconsistent. Most findings focused on the course of mental health disorders, ranging from symptom worsening to new symptoms of anxiety, depression, or insomnia. Evidence on mental health care needs, service utilization, and psychosocial aspects was limited.

CONCLUSION

Limited evidence suggests that individuals with pre-existing mental health disorders who experience Long COVID may be at an increased risk of worsening mental health. However, critical aspects such as care needs, service utilization, and psychosocial factors remain under-researched, highlighting the need for further studies on mental health care for Long COVID.

REVIEW REGISTRATION

Open Science Framework https://osf.io/tqexa .

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

根据世界卫生组织（WHO）的定义，长期新冠、新冠后综合征或PASC（新冠-19急性后遗症）是指在初次感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）3个月后持续出现或出现新的症状，且这些症状持续至少2个月且无其他解释。本综述将全程使用“长期新冠”这一术语。对于患有既往心理健康问题且感染了长期新冠的个体，我们知之甚少。本范围综述旨在概述这些个体，重点关注：1）精神障碍的病程，2）护理需求，3）医疗服务的利用情况，以及4）国际功能、残疾和健康分类（ICF）所概述的心理社会方面。

方法

本综述遵循乔安娜·布里格斯研究所（JBI）的范围综述方法和范围综述的系统评价和Meta分析扩展版（PRISMA）。我们纳入了关注至少有一种既往心理健康诊断且感染长期新冠的个体的报告。纳入了英文或德文的全文报告，无地域限制。于2023年11月1日在PubMed、Embase和PsycINFO中进行文献检索，以获取2020年1月至2023年10月期间发表的记录。六名评审员成对参与筛选过程，独立进行研究选择和数据提取。通过共识解决冲突。进行了引文追踪，并以表格形式对数据进行了叙述性总结。

结果

从4256条初始命中记录和引文追踪中，纳入了8份报告。这些研究具有异质性，包括病历回顾、病例报告、横断面研究和纵向研究。关于长期新冠对既往心理健康状况影响的证据并不一致。大多数研究结果集中在心理健康障碍的病程上，范围从症状恶化到出现焦虑、抑郁或失眠等新症状。关于心理健康护理需求、服务利用和心理社会方面的证据有限。