Muñoz Emily, Washington Cyrus, Benedetto Pasquale, Saad Ali, Kryvenko Oleksandr N, Tejera Dalissa, De La Fuente Macarena Ines, Ivan Michael, Azzam Gregory
Jackson Memorial Hospital, University of Miami, Miami, FL, United States.
Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States.
Front Oncol. 2025 Jun 17;15:1565865. doi: 10.3389/fonc.2025.1565865. eCollection 2025.
Nongeminomatous germ cell tumors (NGGCTs) are aggressive malignancies known for their rapid metastatic potential. Teratomas, a subtype of NGGCTs, can be classified as either mature (benign) or immature (malignant). Immature teratomas carry a higher metastatic risk than mature teratomas due to their embryonic-like tissue composition. Intracranial teratomas are rare in nature and can develop secondary malignancies, such as Wilms tumors. We report the case of a 70-year-old man with a history of prostate cancer who presented with neurological symptoms and was diagnosed with a Wilms tumor arising from an immature teratoma. A heterogenous morphology, including squamous, cartilaginous, and neural differentiation, was revealed upon surgical resection. Despite interventions, the patient experienced rapid disease progression and eventually passed away in hospice care 7 months after the initial diagnosis. This case highlights the complexity of diagnosing and managing NGGCTs, particularly when secondary malignancies arise. Ultimately, it underscores the need for careful diagnosis and precise therapeutic strategies to manage these tumors.
非生殖细胞瘤性生殖细胞肿瘤（NGGCTs）是具有快速转移潜能的侵袭性恶性肿瘤。畸胎瘤是NGGCTs的一种亚型，可分为成熟型（良性）或未成熟型（恶性）。由于其类似胚胎的组织构成，未成熟畸胎瘤比成熟畸胎瘤具有更高的转移风险。颅内畸胎瘤较为罕见，可继发恶性肿瘤，如肾母细胞瘤。我们报告了一例70岁有前列腺癌病史的男性患者，其出现神经症状，被诊断为起源于未成熟畸胎瘤的肾母细胞瘤。手术切除后显示出包括鳞状、软骨和神经分化的异质性形态。尽管进行了干预，患者病情仍迅速进展，最终在初次诊断7个月后在临终关怀中去世。该病例突出了诊断和管理NGGCTs的复杂性，尤其是当继发恶性肿瘤出现时。最终，它强调了对这些肿瘤进行仔细诊断和精确治疗策略的必要性。
