Peles Saar, Khalife Roy, Magliocco Anthony
University of Central Florida College of Medicine, Orlando, FL, U.S.A.
Protean BioDiagnostics, Orlando, FL, U.S.A.
Cancer Diagn Progn. 2025 Jun 30;5(4):429-436. doi: 10.21873/cdp.10456. eCollection 2025 Jul-Aug.
BACKGROUND/AIM: Gastric cancer exhibits significant molecular differences across racial and ethnic groups, influencing prognosis and treatment response. This study aimed to compare the molecular characteristics of gastric cancer between Asian and White populations using data from The Cancer Genome Atlas (TCGA).
TCGA data for gastric cancer patients were analyzed to identify differences in genetic mutations, copy number variations, and transcriptomic profiles between Asian and White populations. Bioinformatics tools and statistical analyses were used to assess molecular alterations and pathway enrichment.
Distinct molecular patterns were observed between the two populations. Asian patients exhibited a higher prevalence of mutations in genes such as and , while White patients showed increased alterations in and . Differences in immune-related gene expression and tumor microenvironment signatures were also noted, suggesting potential implications for targeted therapies and immunotherapy response.
Significant molecular differences exist in gastric cancer between Asian and White populations, showing the need for population-specific treatment strategies. These findings may inform personalized therapeutic approaches and contribute to the advancement of precision oncology.
背景/目的：胃癌在不同种族和族裔群体中表现出显著的分子差异，影响预后和治疗反应。本研究旨在利用癌症基因组图谱（TCGA）的数据比较亚洲和白人人群胃癌的分子特征。
分析胃癌患者的TCGA数据，以确定亚洲和白人人群之间基因突变、拷贝数变异和转录组谱的差异。使用生物信息学工具和统计分析来评估分子改变和通路富集。
在两个人群中观察到不同的分子模式。亚洲患者在诸如 和 等基因中的突变发生率较高，而白人患者在 和 中的改变增加。还注意到免疫相关基因表达和肿瘤微环境特征的差异，这表明对靶向治疗和免疫治疗反应具有潜在影响。
亚洲和白人人群的胃癌存在显著的分子差异，表明需要针对特定人群的治疗策略。这些发现可能为个性化治疗方法提供依据，并有助于精准肿瘤学的发展。
