Tilson M D
Surgery. 1985 Nov;98(5):888-91.
A recent report claimed that an amine in human skin (believed to be pyridinoline) was deficient in specimens from patients with abdominal aortic aneurysms (AAA). Further studies suggest that this work was erroneous in two respects. First, the amine has been isolated and partially characterized; the major component of the peak of interest is a deoxyanalogue of pyridinoline. It may be a collagen cross-link of some biologic importance, because it is not detectable in skin from a patient with Marfan's syndrome. Second, further studies in an additional 19 patients with AAA and an additional 13 controls suggest that this amine is abnormally abundant in skin from patients with AAA. This difference cannot be accounted for by any potential source of artifact that has been traceable. The effects of age, diabetes, sex, race, site of biopsy, and source of specimen (autopsy versus surgery) have been studied; none of these variables can account for the high ratio of pyridinolines to hydroxylysine found in skin from patients with AAA.
最近一份报告称，人体皮肤中的一种胺（据信是吡啶啉）在腹主动脉瘤（AAA）患者的样本中含量不足。进一步的研究表明，这项研究在两个方面存在错误。首先，这种胺已被分离并进行了部分表征；感兴趣的峰的主要成分是吡啶啉的脱氧类似物。它可能是一种具有一定生物学重要性的胶原蛋白交联物，因为在马凡氏综合征患者的皮肤中检测不到它。其次，对另外19例AAA患者和13例对照进行的进一步研究表明，这种胺在AAA患者的皮肤中异常丰富。这种差异无法用任何可追溯的潜在假象来源来解释。已经研究了年龄、糖尿病、性别、种族、活检部位和样本来源（尸检与手术）的影响；这些变量都无法解释AAA患者皮肤中吡啶啉与羟赖氨酸的高比例。
