Li Minzhe, Wei Guimei, Liang Zhixing, Wang Wenyi, Wen Changchun, Sun Lixian, Lin Xiang-Cheng
Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Guangxi Key Laboratory of Information Materials, School of Materials Science and Engineering, Guilin University of Electronic Technology, Guilin, 541004, China.
Mikrochim Acta. 2025 Jul 2;192(8):466. doi: 10.1007/s00604-025-07328-1.
Antibiotics are the primary drugs utilized to combat bacterial infections; however, their overuse and misuse have caused significant harm to human health. Rapid and efficient detection of antibiotics is crucial for food safety and environmental monitoring. Surface-enhanced Raman scattering (SERS) technology offers ultra-high sensitivity for molecular detection. In this study, we introduce a SERS substrate AuNRs-SH-BN (ASBN), which integrates semiconductor boron nitride with noble metal gold nanorods (AuNRs) for the trace detection of antibiotics. The prepared porous boron nitride features a large specific surface area with numerous pores and adsorption sites, facilitating the adsorption of antibiotic molecules. Coupling porous boron nitride with AuNRs generates numerous "hot spots," thereby enhancing the Raman signal. The SERS activity of the ASBN substrate was evaluated using signaling molecules, demonstrating a high enhancement factor (7.13 × 10), excellent uniformity (RSD = 4.45%), and good stability (retaining 87.22% of the initial intensity after 28 days). The linear detection range for tetracycline hydrochloride is in the range 10-10 M. Additionally, significant recoveries of 82.11%‒97.10% were achieved for tetracycline hydrochloride in real samples.
抗生素是用于对抗细菌感染的主要药物；然而，它们的过度使用和滥用已对人类健康造成了重大危害。快速高效地检测抗生素对于食品安全和环境监测至关重要。表面增强拉曼散射（SERS）技术为分子检测提供了超高灵敏度。在本研究中，我们引入了一种SERS基底AuNRs-SH-BN（ASBN），它将半导体氮化硼与贵金属金纳米棒（AuNRs）集成用于抗生素的痕量检测。制备的多孔氮化硼具有大的比表面积，有许多孔隙和吸附位点，便于抗生素分子的吸附。将多孔氮化硼与AuNRs耦合产生大量“热点”，从而增强拉曼信号。使用信号分子评估了ASBN基底的SERS活性，结果表明其具有高增强因子（7.13×10）、优异的均匀性（RSD = 4.45%）和良好的稳定性（28天后保留初始强度的87.22%）。盐酸四环素的线性检测范围为10-10 M。此外，实际样品中盐酸四环素的回收率显著，为82.11%‒97.10%。
