Abbasi Mohammad Mehdi, Khandae Sajjad, Shahabi Mahshad, Attarzadeh Mousa, Karimi Mahdiyeh, Saghafi Hoora, Razeghi Soodeh, Khamseh Fatemeh, Rashidkhani Bahram
Student Research Committee, Department, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran Dementia and Alzheimer association, Tehran, Iran.
Sci Rep. 2025 Jul 2;15(1):23312. doi: 10.1038/s41598-025-05416-z.
The findings on the connection between Alzheimer's disease and the dietary approaches to stop hypertension (DASH) are inconsistent. Additionally, the relationship between Alzheimer's and the DASH diet has not been explored in the Middle East region. This case-control study aimed to evaluate the association between adherence to DASH diet and the risk of Alzheimer's disease. The study included 212 participants (106 cases and 106 controls). Cases were recruited among people in the early stages of the disease who had been diagnosed with Alzheimer's disease within the past six months. Controls were selected from health centers across Tehran. Dietary intake was assessed using a validated 168-item food frequency questionnaire. Four DASH diet indices (Dixon, Mellen, Fung, and Günther) were used to evaluate the adherence. After adjusting for potential confounders, higher adherence to Günther's, Mellen's, and Fung's DASH diet indices were significantly associated with a reduced risk of Alzheimer's disease (Mellen's OR: 0.29; 95% CI: 0.10-0.83; Fung's OR: 0.22; 95% CI: 0.08-0.65; Günther's OR: 0.36; 95% CI: 0.13-1.00). Adherence to DASH dietary pattern might be associated with a decreased risk of Alzheimer's disease. Future studies should aim to investigate the association in a prospective design in the Middle East.
关于阿尔茨海默病与终止高血压饮食方法（DASH）之间联系的研究结果并不一致。此外，中东地区尚未对阿尔茨海默病与DASH饮食之间的关系进行探讨。这项病例对照研究旨在评估坚持DASH饮食与患阿尔茨海默病风险之间的关联。该研究纳入了212名参与者（106例病例和106名对照）。病例从疾病早期阶段且在过去六个月内被诊断为阿尔茨海默病的人群中招募。对照从德黑兰各地的健康中心选取。使用经过验证的168项食物频率问卷评估饮食摄入量。采用四个DASH饮食指数（迪克森、梅伦、冯和京特）来评估依从性。在对潜在混杂因素进行调整后，更高程度地坚持京特、梅伦和冯的DASH饮食指数与降低患阿尔茨海默病的风险显著相关（梅伦的比值比：0.29；95%置信区间：0.10 - 0.83；冯的比值比：0.22；95%置信区间：0.08 - 0.65；京特的比值比：0.36；95%置信区间：0.13 - 1.00）。坚持DASH饮食模式可能与降低患阿尔茨海默病的风险有关。未来的研究应以中东地区的前瞻性设计来调查这种关联为目标。
