Zarean Maryam, Davoodi Soheila, Keikha Mojtaba, Khoshali Mehri, Daniali Seyede Shahrbanoo, Kelishadi Roya
Department of Biology, York University, Toronto, ON, Canada.
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2025 Jul 2;15(1):23487. doi: 10.1038/s41598-025-05049-2.
This meta-analysis examines the relationship between exposure to endocrine-disrupting chemicals, such as phthalates and parabens, which are commonly found in cosmetics, and the risk of developing gestational diabetes mellitus (GDM). Following a systematic search of databases (including PubMed, Scopus, and Web of Science), 14 relevant studies involving 9,503 pregnant women from various regions were identified. After excluding one paper, 11 studies were classified as high-quality, while three received acceptable scores and were included in the analysis. The studies assessed the level of chemical exposure by analyzing urine, serum, or plasma samples. Calculated odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the potential association between maternal exposure and GDM development. The pooled analysis indicated no significant correlation between phthalate exposure during pregnancy and GDM risk, with an OR of 1.01 (95% CI: 0.95-1.08). Subgroup analyses based on participants' location and specific phthalate metabolites consistently showed no significant association with GDM. Limited evidence on parabens also failed to demonstrate a clear link with GDM. Although this meta-analysis found no significant link between these substances and GDM, further investigation is necessary to comprehensively assess the cumulative and long-term effects of endocrine-disrupting chemicals on pregnant women.
这项荟萃分析研究了接触内分泌干扰化学物质（如化妆品中常见的邻苯二甲酸盐和对羟基苯甲酸酯）与患妊娠期糖尿病（GDM）风险之间的关系。在对数据库（包括PubMed、Scopus和Web of Science）进行系统检索后，确定了14项涉及来自不同地区的9503名孕妇的相关研究。排除一篇论文后，11项研究被归类为高质量研究，三项研究获得可接受分数并纳入分析。这些研究通过分析尿液、血清或血浆样本评估化学物质暴露水平。计算比值比（OR）和95%置信区间（CI）用于评估母亲暴露与GDM发生之间的潜在关联。汇总分析表明，孕期邻苯二甲酸盐暴露与GDM风险之间无显著相关性，OR为1.01（95%CI：0.95-1.08）。基于参与者所在地和特定邻苯二甲酸酯代谢物的亚组分析始终显示与GDM无显著关联。关于对羟基苯甲酸酯的有限证据也未能证明与GDM有明确联系。尽管这项荟萃分析未发现这些物质与GDM之间存在显著联系，但仍有必要进行进一步调查，以全面评估内分泌干扰化学物质对孕妇的累积和长期影响。
