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重新思考疟疾消除:安哥拉面临的挑战与解决方案之展望

Rethinking malaria elimination: a perspective on challenges and solutions in Angola.

作者信息

Domingos Edmilson Serra

机构信息

Sagrada Esperança Clinic, Av. Murtala Mohammed, 298, Luanda, Angola.

出版信息

Malar J. 2025 Jul 2;24(1):214. doi: 10.1186/s12936-025-05398-3.

Abstract

BACKGROUND

Multiple challenges hinder malaria control in Angola, including climatic variability, ineffective vector control, population displacement, socioeconomic inequalities, and increasing resistance to anti-malarial drugs and insecticides. These barriers have been further exacerbated by the COVID-19 pandemic, disrupting healthcare services and reversing prior gains. Despite a 36% reduction in malaria mortality since 2000, Angola remains off track to meet the Global Technical Strategy (GTS) targets for 2025, with no significant progress recorded in reducing malaria mortality between 2015 and 2023.

PERSPECTIVES

This paper analyses Angola's malaria landscape, emphasizing that persistent healthcare system weaknesses such as financial instability, workforce shortages, poor disease surveillance, and regional disparities in intervention coverage, necessitate urgent, tailored responses. Drawing from lessons learned in successful malaria elimination programmes in Cabo Verde, Algeria, China, and the recent WHO recommendations, the study recommends the implementation of three integrated strategies: (i) mass drug administration, to rapidly reduce transmission and help consolidate malaria control; (ii) intermittent preventive treatment for school-age children, to protect a high-risk yet often overlooked population; and (iii) post-hospitalization malaria prevention to decrease readmissions and mortality linked to severe malaria episodes.

CONCLUSION

Achieving malaria elimination or a substantial reduction in Angola's disease burden demands increased political commitment, sustainable financing, professional capacity building, and rigorous monitoring. A coordinated, evidence-based approach, aligned with WHO recommendations and tailored to Angola's epidemiological context, is essential to overcoming barriers and accelerating progress toward the 2030 malaria elimination goal.

摘要

背景

多种挑战阻碍了安哥拉的疟疾防治工作,包括气候多变、病媒控制无效、人口流离失所、社会经济不平等,以及对抗疟药物和杀虫剂的耐药性不断增加。新冠疫情进一步加剧了这些障碍,扰乱了医疗服务并使之前取得的成果倒退。尽管自2000年以来疟疾死亡率下降了36%,但安哥拉仍未走上实现2025年全球技术战略(GTS)目标的正轨,2015年至2023年期间在降低疟疾死亡率方面没有取得显著进展。

观点

本文分析了安哥拉的疟疾形势,强调持续存在的医疗系统弱点,如财政不稳定、劳动力短缺、疾病监测不力以及干预措施覆盖范围的地区差异,需要采取紧急、量身定制的应对措施。借鉴佛得角、阿尔及利亚、中国成功的疟疾消除计划的经验教训以及世界卫生组织最近的建议,该研究建议实施三项综合战略:(i)大规模药物管理,以迅速减少传播并帮助巩固疟疾防治;(ii)对学龄儿童进行间歇性预防性治疗,以保护高危但经常被忽视的人群;(iii)出院后疟疾预防,以减少与严重疟疾发作相关的再入院率和死亡率。

结论

要在安哥拉实现疟疾消除或大幅减轻疾病负担,需要加强政治承诺、可持续融资、专业能力建设以及严格监测。采取一种与世界卫生组织建议一致、根据安哥拉的流行病学情况量身定制的协调、循证方法,对于克服障碍并加速朝着2030年疟疾消除目标取得进展至关重要。

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