Zhou Zhihui, Wang Jiawei, Kong Fanhui, Zhang Qianqian
School of Athletic Performance, Shanghai University of Sport, Shanghai, China.
College of P.E. and Sports, Beijing Normal University, Beijing, China.
Front Physiol. 2025 Jun 18;16:1573674. doi: 10.3389/fphys.2025.1573674. eCollection 2025.
This study aimed to examine the effect of 12-week Baduanjin exercise on cognitive function and peripheral blood brain-derived neurotrophic factor (BDNF) levels in the older adults, utilizing a blended online and offline model.
A total of 40 older adults with low physical activity levels were randomly assigned to either Baduanjin group (BG, n = 20, age: 63.75 ± 1.41 years) or control group (CG, n = 20, age: 63.10 ± 1.65 years). The BG participated in 12-week Baduanjin exercise, conducted 3 times per week, integrating both online and offline components. Each session comprised a 60-min structure, including a 10-min warm-up, 40 min of Baduanjin exercise, and a 10-min cool-down period. Cognitive function and peripheral blood BDNF levels were assessed prior to and following the 12-week intervention.
(1) After 12-week intervention, BG exhibited significant improvements in MoCA ( < 0.01), and MoCA of BG was significantly higher than CG ( < 0.05). (2) After 12-week intervention, BG exhibited significant improvements in DST-F ( < 0.05), DST-B ( < 0.05), VFT ( < 0.01), Stroop-A ( < 0.05), and Stroop-RT ( < 0.05). DST-F, DST-B, VFT, and Stroop-A scores of BG were significantly higher than those of the CG ( < 0.05) after intervention. And Stroop-RT was significantly lower than CG (<0.05) after intervention. (3) BDNF levels: After 12-week intervention, BG exhibited significant improvements in BDNF ( < 0.01), and BDNF of BG was significantly higher than CG ( < 0.05). (4) A significant positive linear correlation was identified between MoCA scores and BDNF levels (r = 0.488).
12-week Baduanjin intervention in a blended online-offline model can significantly improve cognitive function in the older adults. The improvement in cognitive levels induced by exercise is accompanied by an increase in peripheral blood BDNF content, and there is a significant positive correlation between the two factors.
本研究旨在利用线上线下相结合的模式，探讨为期12周的八段锦锻炼对老年人认知功能和外周血脑源性神经营养因子（BDNF）水平的影响。
将40名身体活动水平较低的老年人随机分为八段锦组（BG，n = 20，年龄：63.75±1.41岁）和对照组（CG，n = 20，年龄：63.10±1.65岁）。BG组参加为期12周的八段锦锻炼，每周进行3次，融合线上和线下部分。每次课程时长60分钟，包括10分钟热身、40分钟八段锦锻炼和10分钟放松期。在12周干预前后评估认知功能和外周血BDNF水平。
（1）12周干预后，BG组的蒙特利尔认知评估量表（MoCA）得分有显著改善（<0.01），且BG组的MoCA得分显著高于CG组（<0.05）。（2）12周干预后，BG组在简易精神状态检查表-言语流畅性（DST-F）（<0.05）、简易精神状态检查表-词语回忆（DST-B）（<0.05）、词汇流畅性测验（VFT）（<0.01）、斯特鲁普测验-A（<0.05）和斯特鲁普测验-反应时间（Stroop-RT）（<0.05）方面有显著改善。干预后，BG组的DST-F、DST-B、VFT和斯特鲁普测验-A得分显著高于CG组（<0.05）。且干预后Stroop-RT显著低于CG组（<0.05）。（3）BDNF水平：12周干预后，BG组的BDNF有显著改善（<0.01），且BG组的BDNF显著高于CG组（<0.05）。（4）MoCA得分与BDNF水平之间存在显著正线性相关（r = 0.488）。
线上线下相结合模式下为期12周的八段锦干预可显著改善老年人的认知功能。运动引起的认知水平改善伴随着外周血BDNF含量的增加，且这两个因素之间存在显著正相关。
