Nasif Md Abdullah Omar, Haider Najmul, Muntasir Immamul, Qayum Md Omar, Hasan Mohammad Nayeem, Hassan Mohammad Rashedul, Khan Manjur Hossain, Sultana Sharmin, Ferdous Jannatul, Prince Kyaw Thowai Prue, Rudra Mithun, Rahman Mahbubur, Alam Ahmed Nawsher, Shirin Tahmina
Institute of Epidemiology, Disease Control and Research (IEDCR), Ministry of Health and Family Welfare, Mohakhali, Bangladesh.
School of Life Sciences, Faculty of Natural Sciences, Keele University, Keele, United Kingdom.
IJID Reg. 2025 May 8;16:100664. doi: 10.1016/j.ijregi.2025.100664. eCollection 2025 Sep.
We investigated a new outbreak of Chikungunya virus (CHIKV) in Dhaka and nearby areas of Bangladesh in 2024, examining its epidemiology, clinical features, and genomic characteristics.
The Institute of Epidemiology, Disease Control and Research enrolled suspected Chikungunya cases from October 19 to December 31, 2024. Reverse transcription polymerase chain reaction was performed, and positive cases were followed up via telephone between days 21 and 28. The E1 gene of 12 samples was sequenced.
Of 394 enrolled patients, 138 (35%) were CHIKV-positive, mostly male (64.5%) and over 30 years old (83.3%), with 98.6% residing in Dhaka. Common symptoms included fever (100%), arthralgia (97.8%), myalgia (83.2%), and headache (65.0%). While no fatalities were recorded, 14.5% required hospitalization with an average stay of 5.9 days, and patients lost an average of 10.5 workdays. At 28 days, 81% of 58 follow-up patients had persistent symptoms. Both hospitalization and persistent symptoms were associated with having >4 symptoms initially (incidence risk ratio: 1.14; 95% confidence interval: 1.02-1.27 and 1.19; 95% confidence interval: 1.01-1.39, respectively). Sequence analysis identified an E1-K211E substitution, with phylogenetics revealing a distinct East-Central-South-African (ECSA) sub-lineage compared to 2017 strains.
CHIKV is likely to re-emerge in Bangladesh amid the ongoing dengue outbreak, posing a risk of a major outbreak soon. Strengthening efforts to control mosquitoes is essential.
我们调查了2024年在达卡及孟加拉国附近地区新出现的基孔肯雅病毒（CHIKV）疫情，研究其流行病学、临床特征和基因组特征。
流行病学、疾病控制与研究所在2024年10月19日至12月31日期间纳入疑似基孔肯雅热病例。进行逆转录聚合酶链反应，并在第21天至28天通过电话对阳性病例进行随访。对12份样本的E1基因进行测序。
在394名登记患者中，138例（35%）CHIKV呈阳性，大多数为男性（64.5%），年龄超过30岁（83.3%），98.6%居住在达卡。常见症状包括发热（100%）、关节痛（97.8%）、肌痛（83.2%）和头痛（65.0%）。虽然没有记录到死亡病例，但14.5%的患者需要住院治疗，平均住院时间为5.9天，患者平均损失10.5个工作日。在第28天，58名随访患者中有81%仍有持续症状。住院治疗和持续症状均与最初出现>4种症状有关（发病风险比分别为：1.14；95%置信区间：1.02 - 1.27和1.19；95%置信区间：1.01 - 1.39）。序列分析鉴定出一个E1-K211E替代，系统发育分析显示与2017年毒株相比，存在一个独特的东中非 - 南非（ECSA）亚谱系。
在当前登革热疫情期间，基孔肯雅病毒很可能在孟加拉国再次出现，不久后有引发大规模疫情的风险。加强控制蚊虫的工作至关重要。
