[Morphological characteristics of cellular elements in the focus of posttraumatic inflammation in thiamine deficiency].

The influence of vitamin B1-deficiency on the ultrastructure of the cellular elements in the focus of aseptic inflammation in the skeletal muscles was studied in white mice, 2 and 3 days after the infliction of a mechanical trauma. Food B1-hypovitaminosis was induced by keeping the animals on a thiamine-deficient ration during 30 days. Oxythiamine hypovitaminosis was simulated by subcutaneous injections of vitamin B1 antimetabolite--oxythiamine, in a dose of 10 mg/kg, every 12 h, during 10 days. Both types of hypovitaminosis induced similar reactions of the cellular elements. The volume fraction of lysosomes and phagosomes in the macrophage cytoplasma decreased, the volume density of mitochondria increased, differentiation of fibroblasts was delayed. No significant changes were detected in the ultrastructure of neutrophilic granulocytes, eosinophils and lymphocytes. Decrease of macrophage phagocytic activity is one of the main factors in the mechanism of delay of necrotic mass resorption and inhibition of the following development of reparative processes.