Gao Mingxuan, Gong Liya, Zeng Yanmei, Li Dongling, Wen Junyan, Guo Ying, Li Zhujia, Luo Jingwen, Chen Chunling, Wen Ge
Department of Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Department of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Front Neurosci. 2025 Jun 18;19:1612722. doi: 10.3389/fnins.2025.1612722. eCollection 2025.
Abnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the "gut-brain axis" is involved in a wide range of metabolic regulation through neural and endocrine processes, which has become a key breakthrough in revealing the abnormalities of food intake behaviors in T2DM patients.
Exploring the mechanism of action of abnormal regulation of ingestive desire in overweight/obese T2DM patients by integrating multimodal MRI techniques with microbiological analysis based on the gut-brain axis.
Thirty-one patients with overweight/obese type 2 diabetes mellitus (Group A), 17 patients with simple obesity with abnormal glucose metabolism (Group B), and 14 patients with simple obesity with normal glucose metabolism (Group C) were recruited, and clinical data, MRI, and stool specimens were collected to analyze the correlation between the imaging indicators and the intestinal flora, and clinical data.
Compared with Group C, the abundance of and in Group A and Group B was significantly reduced, while the abundance of , , and was significantly increased. Meanwhile, in Group A and Group B, and Bifidobacterium were negatively correlated with HbA1c, thirst score, and FC values of the left supraoccipital gyrus and bilateral thalamus in the population with abnormal glucose metabolism; Bacteroides were negatively correlated with ALFF values of the right inferior frontal gyrus capitellum, and positively correlated with FC values of the left supraoccipital gyrus and bilateral thalamus, and so on.
Abnormal desire to ingest is the result of functional changes in brain regions, dysregulation of flora metabolism and neuroimmune interactions, providing a theoretical basis for clinical diagnosis and treatment targeting the gut-brain axis.
超重/肥胖的2型糖尿病（T2DM）患者食物摄入调节异常是能量摄入失衡的重要原因，研究表明“肠-脑轴”通过神经和内分泌过程参与广泛的代谢调节，这已成为揭示T2DM患者食物摄入行为异常的关键突破点。
基于肠-脑轴，整合多模态磁共振成像（MRI）技术与微生物学分析，探究超重/肥胖T2DM患者摄食欲望调节异常的作用机制。
招募31例超重/肥胖的2型糖尿病患者（A组）、17例糖代谢异常的单纯肥胖患者（B组）和14例糖代谢正常的单纯肥胖患者（C组），收集临床资料、MRI及粪便标本，分析成像指标与肠道菌群及临床资料之间的相关性。
与C组相比，A组和B组的[具体菌属1]和[具体菌属2]丰度显著降低，而[具体菌属3]、[具体菌属4]和[具体菌属5]丰度显著增加。同时，在A组和B组中，双歧杆菌与糖代谢异常人群的糖化血红蛋白（HbA1c）、口渴评分以及左侧枕上回和双侧丘脑的功能连接（FC）值呈负相关；拟杆菌与右侧额下回小头的局部一致性（ALFF）值呈负相关，与左侧枕上回和双侧丘脑的FC值呈正相关等。
摄食欲望异常是脑区功能改变、菌群代谢失调及神经免疫相互作用的结果，为针对肠-脑轴的临床诊断和治疗提供了理论依据。
