Li Leping, Talukder Amlan, Yeung Deryck, Li Yuanyuan, Umbach David M, Gilmore John H, Fan Zheng
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Psychiatry Res Neuroimaging. 2025 Aug;351:112021. doi: 10.1016/j.pscychresns.2025.112021. Epub 2025 Jun 30.
Most EEG studies of MDD examined mean differences in frequency-band-specific power between MDD patients and control subjects; however, a few studies looked for differences in temporal trends in power. We focused on overnight time trends in relative power using polysomnography studies of 544 patients with MDD and 1662 age- and sex-matched controls. We sought to replicate our finding on MDD with an additional 653 patients with depressive disorder (DD) and 1959 age- and sex-matched controls. For each subject, we estimated trends as regression slopes separately for 180 features defined by six frequency bands, five sleep stages, and six brain regions. Relative theta power during stage 2 (N2) non-rapid eye movement (NREM) sleep in the frontal and central regions of the brain increased more rapidly through time in MDD patients than in controls. Similar upward trends of relative theta power were also statistically significant in DD patients. If validated in a longitudinal study, the time trend in relative theta power in the N2 stage of the NREM sleep could potentially serve as a surrogate biomarker for monitoring the responses of patients with depressive disorders to treatment.
大多数关于重度抑郁症（MDD）的脑电图研究考察了MDD患者与对照受试者之间特定频段功率的平均差异；然而，少数研究则寻找功率随时间变化趋势的差异。我们利用对544例MDD患者和1662例年龄及性别匹配的对照进行的多导睡眠图研究，重点关注相对功率的夜间时间变化趋势。我们试图在另外653例抑郁症（DD）患者和1959例年龄及性别匹配的对照中重复我们关于MDD的发现。对于每个受试者，我们分别针对由六个频段、五个睡眠阶段和六个脑区定义的180个特征，将趋势估计为回归斜率。与对照相比，MDD患者大脑额叶和中央区域在第二阶段（N2）非快速眼动（NREM）睡眠期间的相对θ波功率随时间增加得更快。DD患者中相对θ波功率的类似上升趋势在统计学上也具有显著性。如果在纵向研究中得到验证，NREM睡眠N2阶段相对θ波功率的时间变化趋势可能会成为监测抑郁症患者治疗反应的替代生物标志物。
