Savolainen K, Riihimäki V, Muona O, Kekoni J, Luukkonen R, Laine A
Acta Pharmacol Toxicol (Copenh). 1985 Aug;57(2):67-71. doi: 10.1111/j.1600-0773.1985.tb00012.x.
Effects of fixed and fluctuating concentrations of m-xylene in air were studied on human psychophysiological functions. Nine healthy male volunteers were exposed to m-xylene 4 hrs a day, 3 hrs in the morning and 1 hr in the afternoon, with a 40 min. break in between. The subjects were sedentary or exercised at 100 W for 10 min at the beginning of each session in the chamber. The m-xylene concentrations in the air were fixed (8.2 mumol/l; 870 mg/m3) or fluctuated with peaks (5.2-16.4 mumol/l; 550-1740 mg/m3) but the TWA (8 hrs) concentration of m-xylene was always 4.1 mumol/l (435 mg/m3). The two control days, with and without exercise, were similar to the exposure days, but without exposure. Reaction times were measured with a device in which subjects responded to visual and auditory stimuli. Body sway was measured with the subjects' eyes open and closed with a strain gauge transducer platform. Changes in reaction times did not correlate with m-xylene concentrations in the air. Changes of average and maximal body sway were, however, consistently negatively correlated with the intensity of the atmospheric exposure to m-xylene at the beginning of each session in the chamber. Physical exercise combined with exposure to m-xylene improved rather than impaired body sway.
研究了空气中固定浓度和波动浓度的间二甲苯对人体心理生理功能的影响。九名健康男性志愿者每天接触间二甲苯4小时，上午3小时，下午1小时，中间休息40分钟。在实验舱内每次实验开始时，受试者久坐不动或进行10分钟100瓦的运动。空气中间二甲苯的浓度固定为（8.2微摩尔/升；870毫克/立方米）或波动，峰值为（5.2 - 16.4微摩尔/升；550 - 1740毫克/立方米），但间二甲苯的8小时时间加权平均（TWA）浓度始终为4.1微摩尔/升（435毫克/立方米）。两个对照日，一个有运动，一个没有运动，与暴露日相似，但没有暴露。使用一种设备测量反应时间，受试者对视觉和听觉刺激做出反应。使用应变仪传感器平台在受试者睁眼和闭眼时测量身体摇摆。反应时间的变化与空气中间二甲苯的浓度无关。然而，在实验舱内每次实验开始时，平均和最大身体摇摆的变化始终与间二甲苯的大气暴露强度呈负相关。体育锻炼与接触间二甲苯相结合改善了而非损害了身体摇摆。
