久坐行为、身体活动与过敏性鼻炎和哮喘的风险：队列研究和孟德尔随机化研究的证据
Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies.
作者信息
Wang Xiaoyu, Gao Yaya, Lou Lin, Yang Wenjie, Xu Wei, Zhao Yu, Ren Jianjun
机构信息
Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, China.
Center of Biostatistics, Design, Measurement and Evaluation (CBDME), West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, Sichuan, 610041, China.
出版信息
BMC Pulm Med. 2025 Jul 3;25(1):320. doi: 10.1186/s12890-025-03779-7.
BACKGROUND
The causality between movement behaviors [sedentary behavior (SB) and physical activity (PA)] with the prevalence of allergic rhinitis (AR) and asthma remained unclear. This study aimed to examine whether different movement behaviors are risk factors for AR and asthma based on epidemiological and genetic evidence, and to characterize these associations in diverse populations.
METHODS
Based on information of questionnaires and registrations provided by UK Biobank, and large-scale GWAS (Genome-Wide Association Study) data, we designed a cohort study with a follow-up period exceeding 11 years and two-sample Mendelian randomization (MR) analysis to explore the causal associations between movement behaviors (SB and PA) and AR and asthma.
RESULTS
Compared to participants with low SB, those with increased SB had higher risk for asthma (moderate: HR = 1.04, 95% CI: 1.01–1.08, = 0.019; high: HR = 1.14, 95% CI: 1.10–1.18, < 0.001). In contrast, more PA was a preventive factor for asthma (moderate: HR = 0.89, 95% CI: 0.81–0.97, = 0.006; high: HR = 0.9, 95% CI: 0.83–0.99, = 0.026). However, no correlation was found between movement behaviors and AR. The consistent associations between movement behaviors and asthma were also confirmed in male, younger (< 60) and older ( > = 60) populations. However, in females, only an association between SB and increased asthma risk was observed, while no protective effect of PA on asthma was identified. Moreover, genetically-predicted causality was observed between SB and asthma as well as PA and asthma by MR analysis (SB: OR = 1.16, 95% CI: 1.04–1.29, = 0.009; PA: OR = 0.94, 95% CI: 0.88-1.00, = 0.046), which was consistent with the findings of our cohort studies.
CONCLUSIONS
This study highlights the risk of asthma associated with SB and emphasizes the role of PA in mitigating this risk. However, no significant association was found between movement behaviors and AR.
CLINICAL TRIAL NUMBER
Not applicable.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1186/s12890-025-03779-7.
背景
运动行为[久坐行为（SB）和体力活动（PA）]与过敏性鼻炎（AR）和哮喘患病率之间的因果关系尚不清楚。本研究旨在基于流行病学和遗传学证据，探讨不同的运动行为是否为AR和哮喘的危险因素，并在不同人群中描述这些关联。
方法
基于英国生物银行提供的问卷和登记信息以及大规模全基因组关联研究（GWAS）数据，我们设计了一项随访期超过11年的队列研究和两样本孟德尔随机化（MR）分析，以探讨运动行为（SB和PA）与AR和哮喘之间的因果关联。
结果
与低久坐行为参与者相比，久坐行为增加的参与者患哮喘的风险更高（中度：HR = 1.04，95%CI：1.01–1.08，P = 0.019；高度：HR = 1.14，95%CI：1.10–1.18，P < 0.001）。相比之下，更多的体力活动是哮喘的预防因素（中度：HR = 0.89，95%CI：0.81–0.97，P = 0.006；高度：HR = 0.9，95%CI：0.83–0.99，P = 0.026）。然而，未发现运动行为与AR之间存在相关性。运动行为与哮喘之间的一致关联在男性、年龄较小（<60岁）和年龄较大（≥60岁）的人群中也得到了证实。然而，在女性中，仅观察到久坐行为与哮喘风险增加之间的关联，而未发现体力活动对哮喘有保护作用。此外，通过MR分析在久坐行为与哮喘以及体力活动与哮喘之间观察到遗传预测的因果关系（久坐行为：OR = 1.16，95%CI：1.04–1.29，P = 0.009；体力活动：OR = 0.94，95%CI：0.88–1.00，P = 0.046），这与我们队列研究的结果一致。
结论
本研究强调了久坐行为与哮喘相关的风险，并强调了体力活动在减轻这种风险中的作用。然而，未发现运动行为与AR之间存在显著关联。
临床试验编号
不适用。
补充信息
在线版本包含可在10.1186/s12890-025-03779-7获取的补充材料。
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