Mamani-Cori Vilma, Calcina-Asillo Talia Paola, Chino-Mamani Marleny, Mendoza-Quispe Yang Rodrigo, Yucra-Sardón Sidgar Orlando, Arbildo-Vega Heber Isac, Carola Padilla-Cáceres Tania, Quispe-Quispe Betsy, Coronel-Zubiate Franz Tito
Department of General Dentistry, Dentistry School, University of the Altiplano, Puno, Peru.
Department of General Dentistry, Dentistry School, San Martín de Porres University, Chiclayo, Peru.
Front Oral Health. 2025 Jun 19;6:1620432. doi: 10.3389/froh.2025.1620432. eCollection 2025.
Saliva acts as a natural buffer, neutralizing the acids produced by bacterial metabolism. Maintaining salivary pH in a range close to neutrality is essential for enamel remineralization processes. This study aimed to evaluate and compare the effect of different concentrations and formulations of topical fluoride on the regulation of salivary pH in schoolchildren from the Altiplano region of Peru.
A quantitative, longitudinal, double-blind, randomized experimental design was employed. A total of 200 children aged 6-12 years who voluntarily agreed to participate were randomly and equally distributed into four study groups. To ensure homogeneous assignment, sociodemographic variables (sex, family type, age, number of siblings, and frequency of daily brushing) and clinical variables (caries severity and oral hygiene level) were controlled. Data were analyzed using SPSS version 25.0. The Shapiro-Wilk test assessed normality ( < 0.05), while Kruskal-Wallis test was used for between-group comparisons and the Friedman test for intragroup comparisons.
Intragroup analysis revealed statistically differences in salivary pH at initial, post-brushing, 10, 30, 60 min and 24-hours measurements across all groups (Friedman's Test; < 0.001). Between-group comparisons also showed significant differences in salivary pH at 10, 30, 60 min, and at 24 and 48 h (Kruskal-Wallis test; < 0.05).
In conclusion, the 5% fluoride varnish and fluoride gels (1.23% and 2%) demonstrated greater efficacy in regulating salivary pH, especially during the initial hours following application.
唾液作为一种天然缓冲剂，可中和细菌代谢产生的酸。维持唾液pH值接近中性范围对于牙釉质再矿化过程至关重要。本研究旨在评估和比较不同浓度和剂型的局部用氟化物对秘鲁高原地区学龄儿童唾液pH值调节的影响。
采用定量、纵向、双盲、随机实验设计。共有200名自愿同意参与的6至12岁儿童被随机且平均分为四个研究组。为确保均匀分配，对社会人口统计学变量（性别、家庭类型、年龄、兄弟姐妹数量和每日刷牙频率）和临床变量（龋齿严重程度和口腔卫生水平）进行了控制。使用SPSS 25.0版软件进行数据分析。Shapiro-Wilk检验评估正态性（<0.05），而Kruskal-Wallis检验用于组间比较，Friedman检验用于组内比较。
组内分析显示，所有组在初始、刷牙后、10、30、60分钟及24小时测量时唾液pH值存在统计学差异（Friedman检验；<0.001）。组间比较也显示，在10、30、60分钟以及24和48小时时唾液pH值存在显著差异（Kruskal-Wallis检验；<0.05）。
总之，5%的氟化物漆和氟凝胶（1.23%和2%）在调节唾液pH值方面显示出更大的功效，尤其是在应用后的最初几个小时。
