Wences Alejandro H, Peñaloza Lizbeth, Steinrücken Matthias, Siri-Jégousse Arno
LAAS - CNRS, Université de Toulouse, 7 av. du colonel Roche, BP 54200, 31031 Toulouse, cedex 4, France.
Instituto de Investigación de Matemáticas y Actuaría, Universidad del Mar, Campus Huatulco, Carretera Federal No 200, Km 250, 70989 Santa María Huatulco, Oaxaca, Mexico.
Theor Popul Biol. 2025 Jul 2;165:1-9. doi: 10.1016/j.tpb.2025.06.002.
We study the time to the most recent common ancestor (TMRCA) of a sample of finite size in a wide class of genealogical models for populations with deterministically varying size. This is made possible by recently developed results on inhomogeneous phase-type random variables, allowing us to obtain the density and the moments of the TMRCA of time-dependent coalescent processes in terms of matrix formulas. We also provide matrix simplifications permitting a more straightforward calculation. With these results, the TMRCA provides an explanatory variable to distinguish different evolutionary scenarios, and to infer model parameters.
我们研究了在一大类种群大小确定性变化的系谱模型中,有限大小样本的最近共同祖先时间(TMRCA)。这得益于最近关于非齐次相位型随机变量的研究成果,使我们能够通过矩阵公式得到时间依赖合并过程的TMRCA的密度和矩。我们还提供了矩阵简化形式,以便更直接地进行计算。有了这些结果,TMRCA提供了一个解释变量,用于区分不同的进化场景,并推断模型参数。