Bao Yunjia, Li Jiangyuan, Wang Zhiyu, Lv Linxi, Zhu Mingyang
Yueqing People's Hospital, Wenzhou, Zhejiang, 325600, China.
The First Clinical Medical Institute, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
BMC Pulm Med. 2025 Jul 4;25(1):322. doi: 10.1186/s12890-025-03743-5.
Inflammation plays a significant role in the emergence and progression of chronic obstructive pulmonary disease (COPD). Uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel metabolic biomarker that is associated with the risk of inflammation. This study aimed to assess and evaluate COPD by calculating UHR.
The cross-sectional research utilized information from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2011 to 2018. To explore the link between UHR and COPD, a multivariate logistic regression analysis was conducted. In addition, effect analysis, smooth curve fitting, the receiver operating characteristic (ROC) curve analysis, Kaplan-Meier survival analysis, subgroup analysis, mediation analysis and sensitivity analysis were used to further explore the association between UHR and COPD.
688 patients were diagnosed with COPD among 9467 participants. After adjusting for interfering factors, logistic regression analysis revealed a notable correlation between UHR and COPD. Smooth curve fitting indicated a linear association between UHR and COPD. In addition, factors such as gender, smoking status, and hypertension were significantly associated with COPD. ROC curve analysis showed that the diagnostic accuracy of UHR was higher than that of Uric acid (UA) and High-density lipoprotein cholesterol (HDL-C). Higher UHR levels were associated with reduced survival. Subgroup analyses showed that gender, smoking status, and hypertension modified the association between UHR and COPD incidence. Mediation analyses identified C-reactive protein (CRP), triglycerides (TG) and phosphorus as potential mediators between UHR and COPD.
This research uncovered a notable correlation between UHR and COPD. These findings suggested that UHR could be a potential indicator for early diagnosis and intervention during COPD progression.
炎症在慢性阻塞性肺疾病（COPD）的发生和发展中起重要作用。尿酸与高密度脂蛋白胆固醇比值（UHR）是一种与炎症风险相关的新型代谢生物标志物。本研究旨在通过计算UHR来评估和评价COPD。
横断面研究利用了2011年至2018年美国国家健康与营养检查调查（NHANES）的信息。为了探究UHR与COPD之间的联系，进行了多因素逻辑回归分析。此外，还采用了效应分析、平滑曲线拟合、受试者工作特征（ROC）曲线分析、Kaplan-Meier生存分析、亚组分析、中介分析和敏感性分析，以进一步探究UHR与COPD之间的关联。
9467名参与者中有688例被诊断为COPD。在调整干扰因素后，逻辑回归分析显示UHR与COPD之间存在显著相关性。平滑曲线拟合表明UHR与COPD之间存在线性关联。此外，性别、吸烟状况和高血压等因素与COPD显著相关。ROC曲线分析表明，UHR的诊断准确性高于尿酸（UA）和高密度脂蛋白胆固醇（HDL-C）。较高的UHR水平与生存率降低相关。亚组分析表明，性别、吸烟状况和高血压改变了UHR与COPD发病率之间的关联。中介分析确定C反应蛋白（CRP）、甘油三酯（TG）和磷为UHR与COPD之间的潜在中介因素。
本研究发现UHR与COPD之间存在显著相关性。这些发现表明，UHR可能是COPD进展过程中早期诊断和干预的潜在指标。
