Pauletto Guilherme, Voigt Giovanna Isabel Mittmann, de Pellegrin Sidnei Flores, Padoin Yasmin, Bier Carlos Alexandre Souza
Faculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil.
Odontology. 2025 Jul 5. doi: 10.1007/s10266-025-01139-9.
This scoping review aimed to map how radiotherapy can influence endodontic treatment. The protocol of this review is available online ( https://osf.io/aq7fv/ ). The report followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A structured search was conducted in PubMed, Embase, Scopus, and Web of Science up to September 2024. Studies that assessed the influence of radiotherapy on the interaction between endodontic sealers and root dentin, the biomechanical behavior of endodontically treated teeth, and the success rates of therapy were included. There were no restrictions on publication date or language, and in vitro studies, observational studies, and experimental clinical studies were eligible. Two researchers independently selected the articles and extracted the data. Out of 1748 studies identified, 18 met the inclusion criteria-13 in vitro studies and 5 observational studies. Most studies used fixed radiation doses, with radiotherapy administered before endodontic treatment. The results of the in vitro studies demonstrated that radiotherapy reduced the bond strength in all studies for at least one of the tested sealers, significantly increased the amount of residual filling material during retreatment and did not negatively affect apical sealing ability. Moreover, radiotherapy influenced the biomechanical behavior of both intact and endodontically treated teeth. However, the findings of observational studies regarding clinical success rates remain controversial. The reviewed evidence suggests that radiotherapy may impact endodontic treatment outcomes in the mapped contexts. However, the available data are limited and further research is needed to strengthen the evidence in this field.
本范围综述旨在梳理放射治疗如何影响牙髓治疗。本综述的方案可在网上获取（https://osf.io/aq7fv/）。该报告遵循了系统评价和Meta分析扩展版的范围综述首选报告项目（PRISMA-ScR）指南。截至2024年9月，在PubMed、Embase、Scopus和Web of Science中进行了结构化检索。纳入了评估放射治疗对牙髓封闭剂与牙根牙本质之间相互作用、牙髓治疗后牙齿的生物力学行为以及治疗成功率影响的研究。对发表日期或语言没有限制，体外研究、观察性研究和实验性临床研究均符合条件。两名研究人员独立筛选文章并提取数据。在检索到的1748项研究中，18项符合纳入标准，其中13项体外研究和5项观察性研究。大多数研究使用固定辐射剂量，且放射治疗在牙髓治疗前进行。体外研究结果表明，在所有研究中，放射治疗至少对一种受试封闭剂降低了粘结强度，在再治疗期间显著增加了残余充填材料的量，且未对根尖封闭能力产生负面影响。此外，放射治疗影响了完整牙齿和牙髓治疗后牙齿的生物力学行为。然而，关于临床成功率的观察性研究结果仍存在争议。综述证据表明，在所述背景下，放射治疗可能会影响牙髓治疗结果。然而，现有数据有限，需要进一步研究以加强该领域的证据。
