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调节光照水平模式可减少与轮班工作相关的休息/活动干扰。

Modulating light level patterns reduces rest/activity disruption associated with shiftwork.

作者信息

Mandi Varun, Miller Haley, Lee Jeongkyung, Goo Young-Hwa, Moulik Mousumi, Ma Ke, Paul Antoni, Yechoor Vijay K, Figueiro Mariana G

机构信息

Division of Endocrinology and Metabolism, Diabetes and Beta Cell Biology Center, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.

Light and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029 USA.

出版信息

NPJ Biol Timing Sleep. 2025;2(1):27. doi: 10.1038/s44323-025-00043-3. Epub 2025 Jul 3.

DOI:10.1038/s44323-025-00043-3
PMID:40620296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12226348/
Abstract

Long-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice individually housed in cages outfitted with running wheels were exposed to 6 simulated shiftwork light interventions. Mice experiencing high light levels during shiftwork exhibited a significant decrease in activity compared to low light levels during shiftwork and a conventional 12 L:12D condition, indicating circadian misalignment. In contrast, mice experiencing shiftwork in darkness combined with either modulated evening light pulses or circadian blind, vision-permissive light showed similar levels of rest/activity compared to a 12 L:12D condition, with phasor analysis indicating that their 24-h circadian rest/activity patterns were not misaligned. The results show that exposure to light that permits visibility but is below activation of the circadian system during shiftwork can prevent circadian misalignment.

摘要

长期暴露于非标准工作时间表会导致昼夜节律失调，这与一系列疾病有关。为了测试调节光照模式是否能减少轮班工作引起的休息/活动干扰，将30只单独饲养在配备有跑步轮笼子里的雄性C57BL/6 J小鼠暴露于6种模拟轮班工作光照干预中。与轮班期间的低光照水平和传统的12小时光照：12小时黑暗条件相比，在轮班期间经历高光水平的小鼠活动显著减少，表明昼夜节律失调。相比之下，在黑暗中经历轮班工作并结合调制的夜间光脉冲或昼夜节律盲、允许视觉的光照的小鼠，与12小时光照：12小时黑暗条件相比，其休息/活动水平相似，相量分析表明它们的24小时昼夜休息/活动模式没有失调。结果表明，在轮班工作期间暴露于允许可见但低于昼夜节律系统激活水平的光照下可以防止昼夜节律失调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/7a70f9f37f19/44323_2025_43_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/15f7c24e305e/44323_2025_43_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/adfcdabe16ac/44323_2025_43_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/999b1f9c98a5/44323_2025_43_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/2ff69e350574/44323_2025_43_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/5c2ac49fd46a/44323_2025_43_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/8193dddce603/44323_2025_43_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/12036f4064d7/44323_2025_43_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/7a70f9f37f19/44323_2025_43_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/15f7c24e305e/44323_2025_43_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/adfcdabe16ac/44323_2025_43_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/999b1f9c98a5/44323_2025_43_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/2ff69e350574/44323_2025_43_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/5c2ac49fd46a/44323_2025_43_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/8193dddce603/44323_2025_43_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/12036f4064d7/44323_2025_43_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da1b/12226348/7a70f9f37f19/44323_2025_43_Fig8_HTML.jpg

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