Jiang Nannan, Abdul Kadir Azidah, Xie Hui, Wang Li, Yu Hua, Hassan Intan Idiana
School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia.
Bengbu Medical University, Bengbu, Anhui, People's Republic of China.
Clin Interv Aging. 2025 Jul 1;20:951-967. doi: 10.2147/CIA.S512322. eCollection 2025.
With the accelerating ageing population, frailty has emerged as a critical concern among older cancer patients. The purpose of the study was to develop a valid and reliable Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.
The FOAC was developed in 4 phases. Phase 1: Conceptualization and Item Generation:32 items were formulated from the literature. Phase 2: Content validation of the FOAC by modified Delphi method. Phase 3: Face validity index (FVI) was calculated by recording the views of two groups, including older adults with cancer and those with professional roles. Phase 4:Using CGA-determined frailty as the dependent variable, receiver operating characteristic (ROC) curve analysis was conducted using FOAC, FP, and aCGA frailty screening scales as independent variables and their area under the curve (AUC), sensitivity, specificity, cut-off value, predicted value, and accuracy were determined. Internal consistency reliability measurement was assessed with Cronbach's alpha.
The FOAC has 30 items. Physiological dimension (11 items). Psychological & cognitive dimension (12 items). Social support (7 items). the results of this study demonstrated that the overall Cronbach's alpha coefficient of the scale was 0.869.
The FOAC is a valid and reliable frailty screening tool that significantly addresses the problems of existing frailty assessment tools, such as single dimension, low sensitivity, complex scoring, and insufficient clinical applicability. It contributes to guiding healthcare professionals in providing more accurate diagnosis, treatment, and cancer management for older adults.
随着人口老龄化加速，衰弱已成为老年癌症患者的一个关键问题。本研究的目的是在中国开发一种有效且可靠的老年癌症患者综合衰弱评估工具（FOAC）。
FOAC分4个阶段开发。第1阶段：概念化与条目生成：从文献中制定了32个条目。第2阶段：采用改良德尔菲法对FOAC进行内容效度验证。第3阶段：通过记录两组人员的意见来计算表面效度指数（FVI），这两组人员包括老年癌症患者和专业人员。第4阶段：以综合老年评估（CGA）确定的衰弱为因变量，将FOAC、衰弱表型（FP）和CGA衰弱筛查量表作为自变量进行受试者工作特征（ROC）曲线分析，并确定其曲线下面积（AUC）、敏感性、特异性、临界值、预测值和准确性。采用Cronbach's α评估内部一致性信度。
FOAC有30个条目。生理维度（11个条目）。心理与认知维度（12个条目）。社会支持（7个条目）。本研究结果表明，该量表的总体Cronbach's α系数为0.869。
FOAC是一种有效且可靠的衰弱筛查工具，显著解决了现有衰弱评估工具存在的单一维度、低敏感性、评分复杂和临床适用性不足等问题。它有助于指导医疗保健专业人员为老年人提供更准确的诊断、治疗和癌症管理。
