周末补觉与甘油三酯/高密度脂蛋白胆固醇比值的关联。
Association of Weekend Catch-Up Sleep With the Triglyceride/High-Density Lipoprotein Cholesterol Ratio.
作者信息
Shin Moon-Kyung, Kim Dongyeop, Song Tae-Jin
机构信息
Ewha Medical Research Institute, Ewha Womans University College of Medicine, Seoul, KOR.
Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, KOR.
出版信息
Cureus. 2025 Jun 5;17(6):e85429. doi: 10.7759/cureus.85429. eCollection 2025 Jun.
PURPOSE
Insulin resistance affects more than just diabetes, influencing overall health. Weekend catch-up sleep (WCUS) might alleviate the adverse health outcomes of ongoing sleep deprivation. The triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio serves as an effective marker for insulin resistance. This study aimed to investigate the association between WCUS and the TG/HDL ratio according to gender and weekday sleep duration.
METHODS
We analyzed nationwide data from the 2019-2021 Korean National Health and Nutrition Examination Survey (KNHANES), which included 10,562 participants: 4,611 male participants (43.7%) and 5,951 female participants (56.3%). Participants' sleep data were collected through self-reported questionnaires. WCUS was divided into the following categories: ≤0 hours, >0-1 hours, >1-2 hours, and >2 hours. Weekday sleep was categorized into three groups: ≤6 hours, >6-8 hours, and >8 hours.
RESULTS
The number of participants and their percentages for WCUS were as follows: 7,152 (62.7%) for ≤0 hours, 1,163 (11.6%) for >0-1 hours, 1,275 (14.3%) for >1-2 hours, and 972 (11.5%) for >2 hours. In multivariable analysis, WCUS (>2 hours) was inversely associated with the TG/HDL ratio (ß coefficient = -0.22, 95% confidence interval (CI): -0.38, -0.06, p = 0.006; odds ratio (OR) = 0.74, 95% CI: 0.57, 0.96, p = 0.031 for TG/HDL > 3.9), and with weekday sleep < 6 hours (OR = 0.68, 95% CI: 0.46, 0.99, p = 0.025). Considering gender differences, the association between WCUS (>2 hours) and the TG/HDL ratio showed a borderline inverse correlation, particularly among male participants (β = -0.41, 95% CI: -0.70, -0.12, p = 0.006; OR = 0.69, 95% CI: 0.51, 0.94, p = 0.052 for TG/HDL > 3.9; OR = 0.65, 95% CI: 0.41, 1.03, p = 0.087 for weekday sleep < 6). No significant association between WCUS (>2 hours) and the TG/HDL ratio was observed in female participants.
CONCLUSION
The WCUS (>2 hours) had an inverse association with the TG/HDL ratio in male participants, which may have a beneficial effect on insulin resistance.
目的
胰岛素抵抗不仅影响糖尿病，还会影响整体健康。周末补觉（WCUS）可能会减轻持续睡眠不足对健康的不良影响。甘油三酯/高密度脂蛋白胆固醇（TG/HDL）比值是胰岛素抵抗的有效标志物。本研究旨在根据性别和工作日睡眠时间，探讨WCUS与TG/HDL比值之间的关联。
方法
我们分析了2019 - 2021年韩国国家健康与营养检查调查（KNHANES）的全国性数据，该调查包括10,562名参与者：4,611名男性参与者（43.7%）和5,951名女性参与者（56.3%）。参与者的睡眠数据通过自我报告问卷收集。WCUS分为以下几类：≤0小时、>0 - 1小时、>1 - 2小时和>2小时。工作日睡眠分为三组：≤6小时、>6 - 8小时和>8小时。
结果
WCUS的参与者数量及其百分比分别为：≤0小时的有7,152人（62.7%），>0 - 1小时的有1,163人（11.6%），>1 - 2小时的有1,275人（14.3%），>2小时的有972人（11.5%）。在多变量分析中，WCUS（>2小时）与TG/HDL比值呈负相关（β系数 = -0.22，95%置信区间（CI）：-0.38，-0.06，p = 0.006；TG/HDL>3.9时的优势比（OR） = 0.74，95% CI：0.57，0.96，p = 0.031），且与工作日睡眠<6小时相关（OR = 0.68，95% CI：0.46，0.99，p = 0.025）。考虑性别差异，WCUS（>2小时）与TG/HDL比值之间的关联显示出临界负相关，特别是在男性参与者中（TG/HDL>3.9时，β = -0.41，95% CI：-0.70，-0.12，p = 0.006；OR = 0.69，95% CI：0.51，0.94，p = 0.052；工作日睡眠<6小时时，OR = 0.65，95% CI：0.41，1.03，p = 0.087）。在女性参与者中，未观察到WCUS（>2小时）与TG/HDL比值之间的显著关联。
结论
WCUS（>2小时）与男性参与者的TG/HDL比值呈负相关，这可能对胰岛素抵抗有有益影响。
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