Gyani Rishikant, Goel Apul, Sankhwar Satyanarayan, Singh Bhupendra P, Kumar Manoj, Singh Vivek Kumar
Urology, King George's Medical University, Lucknow, IND.
Urology, Institute of Medical Sciences, Varanasi, IND.
Cureus. 2025 Jun 4;17(6):e85352. doi: 10.7759/cureus.85352. eCollection 2025 Jun.
Introduction This study aimed to investigate the relationship between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in a North Indian population, as well as to assess the influence of age, serum prostate-specific antigen (PSA), and testosterone levels on this association. Materials and methods A cross-sectional study was conducted at King George's Medical University, Lucknow, India, involving 183 men aged ≥50 years presenting with LUTS or benign prostatic hyperplasia (BPH). The severity of ED was assessed using the International Index of Erectile Function-15 (IIEF-15), while LUTS severity was measured using the International Prostate Symptom Score (IPSS). Serum PSA and testosterone levels were evaluated. Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 26.0 (Released 2018; IBM Corp., Armonk, NY, United States), with a significance level set at p < 0.05. Results The patients' mean ± SD age was 63.13 ± 8.98 years. The severity of LUTS was classified as mild in 67 patients (36.6%), moderate in 62 (33.8%), and severe in 54 (29.5%). ED was categorized as mild in 92 patients (50.3%), moderate in 73 (39.9%), and severe in 18 (9.8%). A significant correlation was found between ED severity and increasing age (p < 0.001), as well as with higher IPSS (p < 0.05). Additionally, ED was significantly associated with comorbidities, including hypertension (HTN) and diabetes mellitus (DM) (p < 0.05). Furthermore, IIEF-15 scores showed a significant correlation with testosterone levels (r = 0.679, p < 0.001). No significant correlation was found between ED severity and serum PSA levels. Conclusions This study found a significant association between ED and the severity of LUTS in men with BPH. The data revealed that patients over 79 years of age tended to have lower testosterone levels, and the presence of comorbidities such as HTN and DM emerged as major risk factors for ED. These findings highlight the significance of adopting a comprehensive, multifactorial approach to assess and manage ED in patients with LUTS.
引言 本研究旨在调查印度北部人群中勃起功能障碍（ED）与下尿路症状（LUTS）之间的关系，并评估年龄、血清前列腺特异性抗原（PSA）和睾酮水平对这种关联的影响。
材料与方法 在印度勒克瑙的乔治国王医科大学进行了一项横断面研究，纳入了183名年龄≥50岁且有LUTS或良性前列腺增生（BPH）的男性。使用国际勃起功能指数-15（IIEF-15）评估ED的严重程度，同时使用国际前列腺症状评分（IPSS）测量LUTS的严重程度。评估血清PSA和睾酮水平。使用IBM SPSS Statistics for Windows 26.0版（2018年发布；IBM公司，美国纽约州阿蒙克）进行统计分析，显著性水平设定为p<0.05。
结果 患者的平均年龄±标准差为63.13±8.98岁。LUTS严重程度分类为轻度的有67例患者（36.6%），中度的有62例（33.8%），重度的有54例（29.5%）。ED分类为轻度的有92例患者（50.3%），中度的有73例（39.9%），重度的有18例（9.8%）。发现ED严重程度与年龄增加（p<0.001）以及较高的IPSS（p<0.05）之间存在显著相关性。此外，ED与包括高血压（HTN）和糖尿病（DM）在内的合并症显著相关（p<0.05）。此外，IIEF-15评分与睾酮水平显示出显著相关性（r = 0.679，p<0.001）。未发现ED严重程度与血清PSA水平之间存在显著相关性。
结论 本研究发现BPH男性中ED与LUTS严重程度之间存在显著关联。数据显示，79岁以上的患者睾酮水平往往较低，而HTN和DM等合并症的存在是ED的主要危险因素。这些发现凸显了采用综合、多因素方法评估和管理LUTS患者ED的重要性。
