Li Wenqiang, Wen Youli, Fan Yuting, Hu Zefu, Deng Zhiping, Huang Qian
Department of Respiratory and Critical Care Medicine, Zigong First People's Hospital, Zigong, Sichuan Province, 643000, People's Republic of China.
Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2025 Jul 2;20:2161-2171. doi: 10.2147/COPD.S515649. eCollection 2025.
This study aims to investigate the association between the Life's Crucial 9 (LC9) score and chronic obstructive pulmonary disease (COPD) in middle-aged and older adults.
We screened the NHANES database for data from 2007-2018. Logistic regression analysis and subgroup analysis were used to explore the association between LC9 score and COPD in middle-aged and older adults. Additionally, restricted cubic spline (RCS) was plotted to visually depict the dose-response relationship between the two.
A total of 12,030 participants were included, of whom 815 had COPD. After multivariate adjustment, the LC9 score was found to be inversely associated with COPD diagnosis. The RCS visually demonstrated a linear decreasing relationship between the two. Furthermore, subgroup analysis revealed no significant interaction across different subgroups, except for education level.
The LC9 score is linearly and inversely associated with COPD diagnosis. Higher LC9 scores are associated with a lower COPD diagnosis in individuals aged 40 and above.
本研究旨在调查中老年人群中生命关键9分（LC9）评分与慢性阻塞性肺疾病（COPD）之间的关联。
我们在国家健康与营养检查调查（NHANES）数据库中筛选了2007年至2018年的数据。采用逻辑回归分析和亚组分析来探讨中老年人群中LC9评分与COPD之间的关联。此外，绘制了限制立方样条图（RCS）以直观描述两者之间的剂量反应关系。
共纳入12,030名参与者，其中815人患有COPD。经过多变量调整后，发现LC9评分与COPD诊断呈负相关。RCS直观显示两者之间呈线性下降关系。此外，亚组分析显示，除教育水平外，不同亚组之间无显著交互作用。
LC9评分与COPD诊断呈线性负相关。在40岁及以上人群中，较高的LC9评分与较低的COPD诊断相关。
