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泌尿外科基于循证医学的术后加速康复(ERAS)实践与未来发展:基于GRADE系统的多维评估

Evidence-based practice and future development of enhanced recovery after surgery (ERAS) in urology: a multidimensional assessment based on the GRADE system.

作者信息

Long Xuezhi, Du Xiaoqin, Wang Yubo, Qiu Qiuxia, Wu Jianhao, Huang Yueting, Wen Zhipeng, Zeng Binghao, Liang Jianfeng, Pan Yanchun, Zhao Yan, Zeng Guohua, Gu Di

机构信息

Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Guangdong Provincial Key Laboratory of Urology, Guangzhou, China.

出版信息

J Robot Surg. 2025 Jul 7;19(1):358. doi: 10.1007/s11701-025-02506-y.


DOI:10.1007/s11701-025-02506-y
PMID:40622655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12234605/
Abstract

Enhanced recovery after surgery (ERAS) pathways in urology harness multidisciplinary, evidence-based interventions to attenuate surgical stress, expedite recovery, and reduce complications. In this PRISMA-guided review of 80 core publications (23 RCTs, 6 meta-analyses, 9 systematic reviews, 15 guidelines/consensus statements, 18 observational studies, 10 narrative reviews) from 1997 to 2025, we applied ROB 2.0 and GRADE methodology to classify 20 perioperative elements. Sixteen elements-such as preoperative education, carbohydrate loading, goal-directed fluid therapy, multimodal analgesia, early mobilisation, and early oral feeding-achieved high-quality evidence with strong recommendations (A1); three elements (preoperative medical optimisation, fasting regimen, sedative use) received moderate-quality, weak recommendations (B2); and one element (audit) was supported by low-quality, weak recommendation (C2). Implementation of A1 elements in radical prostatectomy, cystectomy, and nephrectomy shortened hospital stay by 1-3 days, cut complication rates by up to 30%, and reduced opioid consumption by approximately 30%. Key challenges include standardising fluid management for minimally invasive and outpatient procedures, improving protocol adherence, and integrating patient-reported outcomes. Future work should prioritise multicenter RCTs for moderate-evidence elements, cost-effectiveness analyses, and development of urology-specific ERAS guidelines incorporating digital monitoring and personalised risk stratification.

摘要

泌尿外科手术加速康复(ERAS)路径采用多学科、循证干预措施来减轻手术应激、加速康复并减少并发症。在这项由PRISMA指导的对1997年至2025年80篇核心出版物(23项随机对照试验、6项荟萃分析、9项系统评价、15项指南/共识声明、18项观察性研究、10项叙述性综述)的综述中,我们应用ROB 2.0和GRADE方法对20个围手术期要素进行分类。16个要素——如术前教育、碳水化合物负荷、目标导向液体治疗、多模式镇痛、早期活动和早期经口进食——获得了高质量证据并得到强烈推荐(A1);3个要素(术前医疗优化、禁食方案、镇静剂使用)获得中等质量、弱推荐(B2);1个要素(审核)得到低质量、弱推荐(C2)。在根治性前列腺切除术、膀胱切除术和肾切除术中实施A1要素可使住院时间缩短1 - 3天,并发症发生率降低多达30%,阿片类药物消耗量减少约30%。关键挑战包括规范微创和门诊手术的液体管理、提高方案依从性以及整合患者报告的结果。未来的工作应优先开展针对中等证据要素的多中心随机对照试验、成本效益分析,以及制定纳入数字监测和个性化风险分层的泌尿外科特异性ERAS指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfc0/12234605/c3a188957a77/11701_2025_2506_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfc0/12234605/c3a188957a77/11701_2025_2506_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfc0/12234605/c3a188957a77/11701_2025_2506_Fig1_HTML.jpg

相似文献

[1]
Evidence-based practice and future development of enhanced recovery after surgery (ERAS) in urology: a multidimensional assessment based on the GRADE system.

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[2]
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[3]
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引用本文的文献

[1]
Comment on "Evidence-based practice and future development of enhanced recovery after surgery (ERAS) in urology: a multidimensional assessment based on the GRADE system".

J Robot Surg. 2025-9-4

本文引用的文献

[1]
Early ureteral stent removal reduces urinary tract infection risk without increasing complications in living donor kidney transplantation: a systematic review and meta-analysis.

Clin Transplant Res. 2025-4-25

[2]
Robot-assisted tubeless radical cystectomy: Is the absence of ureteral drainage a mistake?

Fr J Urol. 2025-4-15

[3]
Optimal stenting duration following ureteroscopy and nephrolithotomy: systematic review and meta-analysis.

BMC Urol. 2025-4-7

[4]
Prospective study on the effects of mechanical bowel preparation under the enhanced recovery after surgery concept on electrolyte disturbances and functional recovery after robotic surgery for urologic tumors in older adults.

BMC Urol. 2024-8-28

[5]
Tip bendable suction ureteral access sheath versus traditional sheath in retrograde intrarenal stone surgery: an international multicentre, randomized, parallel group, superiority study.

EClinicalMedicine. 2024-7-5

[6]
Clinical impact of an enhanced recovery protocol implementation for nephrectomy and radical prostatectomy.

Fr J Urol. 2024-9

[7]
Assessing the perioperative outcomes of abdominal drain omission after robot-assisted partial nephrectomy.

Sci Rep. 2024-4-15

[8]
The Effect of Epidural Analgesia on Quality of Recovery (QoR) after Open Radical Nephrectomy: Randomized, Prospective, and Controlled Trial.

J Pers Med. 2024-2-8

[9]
Enhanced recovery after surgery (ERAS ) Society abdominal and thoracic surgery recommendations: A systematic review and comparison of guidelines for perioperative and pharmacotherapy core items.

World J Surg. 2024-3

[10]
Combined spinal and epidural anaesthesia for open radical cystectomy: A controlled study.

BJUI Compass. 2023-10-3

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