Kaneko F, Takahashi Y, Muramatsu R, Adachi K, Miura Y, Nakane A, Minagawa T
Br J Dermatol. 1985 Sep;113(3):313-8. doi: 10.1111/j.1365-2133.1985.tb02083.x.
We have studied NK cell activity and numbers in the peripheral blood obtained from patients with Behcet's disease and from normal healthy controls. NK cell activity in the peripheral blood of patients in the clinically-active stage of Behcet's disease was significantly lower than that of patients in the inactive stage and normal controls. In contrast, it was observed that the actual number of NK cells was markedly increased in the peripheral blood of patients with active disease. The addition of alpha-interferon (INF-alpha) to these cells showed significant augmentation of NK cell activity. These results suggest that the patients with active Behcet's disease lack a factor which activates NK cells.
我们研究了白塞病患者和正常健康对照者外周血中的自然杀伤（NK）细胞活性及数量。处于白塞病临床活动期患者的外周血NK细胞活性显著低于非活动期患者及正常对照者。相反，观察到活动期疾病患者外周血中NK细胞的实际数量明显增加。向这些细胞中添加α干扰素（INF-α）后，NK细胞活性显著增强。这些结果表明，活动期白塞病患者缺乏一种激活NK细胞的因子。
