Takeuchi-Hatanaka Kazu, Ito Masahiro, Hayashi Yoshihiro, Maruyama Hiroe, Kono Hiroyuki, Shinoda-Ito Yuki, Omori Kazuhiro, Takashiba Shogo
Department of Periodontics and Endodontics, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Shiomi dental clinic, 3-12-13 Kuzuhamisaki, Hirakata, 573-1112, Japan.
Clin Oral Investig. 2025 Jul 9;29(8):379. doi: 10.1007/s00784-025-06456-5.
Propolis possesses antibacterial, anti-inflammatory, and antioxidant properties. While its application in oral care has garnered significant attention, evidence supporting its effectiveness against periodontal bacteria is limited. This study used a randomized double-blind protocol to assess the safety and efficacy of toothpaste containing propolis compared to a placebo in patients undergoing supportive periodontal therapy (SPT).
Thirty-two participants in SPT were randomized into two groups: toothpaste containing 2.5% ethanol-extracted propolis (EEP) and a placebo without EEP. Participants brushed twice daily for four weeks, and clinical parameters, bacterial counts, and salivary characteristics were assessed before and after the intervention.
The propolis group showed a significant reduction in periodontal pocket depth ( = 0.006), with a mean depth of 3.80 mm compared to 4.35 mm in the placebo group. Bleeding on probing was significantly reduced in both groups ( = 0.032 in the propolis group and 0.0498 in the placebo group), but did not differ between groups. Total bacterial and () counts did not differ significantly between the groups; however, the number of patients with decreased was slightly larger than those in the placebo group (not significant). Additionally, saliva acidity decreased significantly in the propolis group ( = 0.041), suggesting a shift toward a less pathogenic oral environment. No adverse events were observed.
These findings suggest that propolis may contribute to stabilizing periodontal disease during supportive periodontal therapy by modulating salivary acidity.
Periodontal pocket depth and the rate of bleeding on probing are reduced, along with decreased saliva acidity. Meanwhile, the levels of in the periodontal pockets remain low. Propolis-dentifrice may help alleviate gingival inflammation during SPT.
Registered in the University Hospital Medical Information Network Clinical Trial Registry (ID: UMIN000029554).
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蜂胶具有抗菌、抗炎和抗氧化特性。虽然其在口腔护理中的应用已引起广泛关注，但支持其对牙周细菌有效性的证据有限。本研究采用随机双盲方案，评估含蜂胶牙膏与安慰剂相比，在接受支持性牙周治疗（SPT）患者中的安全性和有效性。
32名接受SPT的参与者被随机分为两组：含2.5%乙醇提取蜂胶（EEP）的牙膏组和不含EEP的安慰剂组。参与者每天刷牙两次，共四周，干预前后评估临床参数、细菌计数和唾液特征。
蜂胶组牙周袋深度显著降低（=0.006），平均深度为3.80毫米，而安慰剂组为4.35毫米。两组探诊出血均显著减少（蜂胶组=0.032，安慰剂组=0.0498），但组间无差异。两组总细菌和（）计数无显著差异；然而，数量减少的患者人数略多于安慰剂组（无统计学意义）。此外，蜂胶组唾液酸度显著降低（=0.041），表明口腔环境向致病性较低的方向转变。未观察到不良事件。
这些发现表明，蜂胶可能通过调节唾液酸度，在支持性牙周治疗期间有助于稳定牙周疾病。
牙周袋深度和探诊出血率降低，同时唾液酸度降低。与此同时，牙周袋中的水平保持较低。含蜂胶牙膏可能有助于在SPT期间减轻牙龈炎症。
在大学医院医学信息网络临床试验注册中心注册（ID：UMIN000029554）。
[图片：见正文]
