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用于超快腔内药物跨生物屏障递送的多孔涂层球囊的压力驱动微注射（PMI）

Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers.

作者信息

Qian Honglin, Wang Jing, Dai Zhaohe, Guo Yirong, Liu Ke, Li Xinyi, Hu Meng, Yu Yan, Wang Jiarong, Lai Yuxian, Ren Kefeng, Ji Jian

机构信息

State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Xiaoshan District, Hangzhou, 311200, China.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.

出版信息

Sci Adv. 2025 Jul 11;11(28):eadv1182. doi: 10.1126/sciadv.adv1182. Epub 2025 Jul 9.

DOI:10.1126/sciadv.adv1182
PMID:40632848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12239961/
Abstract

Biological barriers play a crucial role in safeguarding the human body against pathogens yet pose severe challenges to efficient delivery of therapeutic drugs. Here, we introduce a pressure-driven microinjection (PMI) strategy for the robust and versatile delivery of functional species against biological barriers. With the benefits of elastic porous coating, this strategy enables the capillary suction of drug solutions, localized delivery, and ultrafast penetration through biological barriers by gentle pressure treatment. The penetration capacity is demonstrated by an unprecedented depth (~150 micrometers) of bovine serum albumin (66.4 kilodaltons) across aortic vessels under pressing for only 60 seconds. This spongy coating-based PMI technique can be integrated with medical balloon devices, offering endoluminal treatment within blood vessels, tracheas, and intestines. The in vivo evaluation indicated efficient trans-vascular delivery of 4-octyl itaconate, markedly reducing neointima hyperplasia. This PMI strategy provides a crucial insight for penetrative drug delivery across complex biological barriers.

摘要

生物屏障在保护人体免受病原体侵害方面发挥着关键作用，但对治疗药物的有效递送构成了严峻挑战。在此，我们介绍一种压力驱动微注射（PMI）策略，用于针对生物屏障进行功能物质的强大且通用的递送。借助弹性多孔涂层的优势，该策略能够实现药物溶液的毛细管抽吸、局部递送，并通过温和的压力处理实现对生物屏障的超快穿透。通过在仅施压60秒的情况下，牛血清白蛋白（66.4千道尔顿）在主动脉血管中前所未有的深度（约150微米）展示了其穿透能力。这种基于海绵状涂层的PMI技术可与医用球囊装置集成，实现血管内、气管和肠道内的腔内治疗。体内评估表明，衣康酸辛酯可有效经血管递送，显著减少新生内膜增生。这种PMI策略为跨复杂生物屏障的穿透性药物递送提供了关键见解。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f20e/12239961/d61004f152c9/sciadv.adv1182-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f20e/12239961/80d66c772a63/sciadv.adv1182-f1.jpg
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