Zhang Yan, Liu Xiaoyu, Wang Jingpu, Du Le, Ma Yanyun, Liu Wei, Ye Rui, Yang Yali, Xu Hui
Department of Dermatology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, State Key Laboratory of Medical Genomics, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Clin Cosmet Investig Dermatol. 2022 Apr 13;15:631-642. doi: 10.2147/CCID.S349401. eCollection 2022.
As the human body's largest organ exposed to the external environment, the skin suffers from internal and external aging factors, leading to wrinkles, loss of elasticity, sagging, and rough appearance. However, little is known of the characteristics of skin aging of different body parts in Chinese women. Here, we study the signs of extrinsic skin aging in different body parts to identify the knowledge map of manifestations of aging in Chinese women.
Wrinkle and texture phenotypes and collagen samples from the face, neck, hands, and arms of 326 Chinese women were collected. The correlations between phenotypes and ages and the differences in phenotypes by age were evaluated.
The wrinkle and texture phenotypes around the eyes and mouth and of the hands were strongly correlated with age. Ages 32 and 58 showed the largest number of differentially changed aging phenotypes. The number of aging phenotypes increased sharply between the ages of 24 and 30, suggesting that the skin was undergoing rapid aging. Eye aging was the most rapidly changing phenotype between 19 and 30 years old. Wrinkles at the corner of the eyes showed a significant difference in the older group, suggesting an early onset and long-term effects.
This is the first study to be performed on the characteristics of skin aging among Chinese women that takes account of multiple areas of the body. It was found that 24 years old was the time point at which the skin begins to age in Chinese women. This provides important clues for aging-related research and personalized skin care.
皮肤作为人体暴露于外部环境的最大器官，会受到内外多种衰老因素影响，导致皱纹、弹性丧失、松弛及外观粗糙。然而，中国女性不同身体部位皮肤衰老的特征鲜为人知。在此，我们研究不同身体部位外在皮肤衰老的迹象，以确定中国女性衰老表现的知识图谱。
收集了326名中国女性面部、颈部、手部和手臂的皱纹及纹理表型和胶原蛋白样本。评估了表型与年龄之间的相关性以及不同年龄组表型的差异。
眼周、口周及手部的皱纹和纹理表型与年龄密切相关。32岁和58岁时出现的衰老表型差异变化最多。24岁至30岁之间衰老表型数量急剧增加，表明皮肤正在快速衰老。19岁至30岁之间眼部衰老是变化最迅速的表型。眼角皱纹在老年组中存在显著差异，提示其发病早且影响持久。
这是首次针对中国女性多个身体部位皮肤衰老特征开展的研究。研究发现24岁是中国女性皮肤开始衰老的时间点。这为衰老相关研究及个性化皮肤护理提供了重要线索。
