Kendler K S
Br J Psychiatry. 1985 Jul;147:48-53. doi: 10.1192/bjp.147.1.48.
Substantial evidence suggests that genetic factors contribute to the aetiology of both schizophrenia and alcoholism, when they occur alone. To examine the role of genetic factors in schizophrenia and alcoholism when they occur together in the same individual, the frequency of both conditions was investigated in the co-twins of 34 monozygotic (MZ) and 47 dizygotic (DZ) index twins with a diagnosis of both schizophrenia and alcoholism. Both disorders alone were significantly more common in the MZ than in the DZ co-twins, suggesting that individuals suffering from schizophrenia and alcoholism have a genetic predisposition to both disorders, which is of the same nature as that which causes the two when they occur alone. In the co-twins of the MZ index twins, the diagnoses of schizophrenia and alcoholism were uncorrelated, indicating that the specific environmental factors of causal importance in the two disorders are not closely related.
大量证据表明，当精神分裂症和酗酒单独出现时，遗传因素在它们的病因学中起作用。为了研究遗传因素在同一个体中同时出现精神分裂症和酗酒时所起的作用，对34对诊断为精神分裂症和酗酒的单卵（MZ）双胞胎及47对双卵（DZ）双胞胎的共患双胞胎中这两种疾病的发生率进行了调查。单独来看，这两种疾病在MZ共患双胞胎中比在DZ共患双胞胎中明显更常见，这表明患有精神分裂症和酗酒的个体对这两种疾病都有遗传易感性，这种遗传易感性与这两种疾病单独出现时的病因性质相同。在MZ索引双胞胎的共患双胞胎中，精神分裂症和酗酒的诊断不相关，这表明在这两种疾病中起因果作用的特定环境因素并非密切相关。
