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免疫功能正常宿主的急性间质性胰腺炎伴假性囊肿:非典型表现的病例报告及文献复习

Acute interstitial pancreatitis with pseudocyst in an immunocompetent host: A case report on an atypical presentation and review of literature.

作者信息

Thaker Shivam, Acharya Raviraj V, Banerjee Barnini, Shridhar Meghana, Ramamoorthi Kusugodlu, Kini K Yogesh

机构信息

Kasturba Medical College, MAHE, Manipal, India.

Department of Medicine, Kasturba Medical College, Manipal, India.

出版信息

IDCases. 2025 Jun 18;41:e02291. doi: 10.1016/j.idcr.2025.e02291. eCollection 2025.

Abstract

We report an atypical occurrence of a -infected pancreatic pseudocyst in an immunocompetent patient. A 24-year-old male presented to the clinic with a history of sudden-onset intermittent abdominal pain and fever for the past 3 days. Examination found a soft abdomen, with epigastric and left lumbar tenderness with guarding. An abdominal ultrasound revealed a gaseous abdomen with mild hepatosplenomegaly and three anechoic collections in the pancreas with septations, suspected to be pseudocysts in the uncinate process and body of the pancreas. A pigtail catheter was inserted to drain the pus-filled cyst, and the fluid culture was positive for ceftazidime-sensitive using MALDI-TOF of growth from culture in blood and McConkey agar. The regimen of Inj Ceftazidime for 21 days was started. A pigtail catheter was used to drain the pancreatic collection till the drained fluid was less than 10 mL for 3 days. The patient was discharged in good condition. This case presents an uncommon presentation of infection in a pseudocyst, particularly in an immunocompetent host, which provides a unique insight into the novel properties of the bacteria, including elevated endotoxin-like lipopolysaccharide activity, which is essential in the pathogenesis in this case or similar presentations.

摘要

我们报告了一例免疫功能正常患者发生的非典型α感染性胰腺假性囊肿。一名24岁男性因过去3天突发间歇性腹痛和发热前来就诊。检查发现腹部柔软,上腹部和左腰部有压痛伴肌紧张。腹部超声显示气腹,轻度肝脾肿大,胰腺内有三个有分隔的无回声区,怀疑是胰腺钩突和体部的假性囊肿。插入一根猪尾导管以引流充满脓液的囊肿,通过对血液和麦康凯琼脂培养基上培养物的基质辅助激光解吸电离飞行时间质谱分析,液体培养对头孢他啶敏感呈阳性。开始使用头孢他啶注射液治疗21天。使用猪尾导管引流胰腺积液,直至引流液连续3天少于10毫升。患者康复出院。该病例呈现了假性囊肿感染的罕见表现,尤其是在免疫功能正常的宿主中,这为了解细菌的新特性提供了独特视角,包括内毒素样脂多糖活性升高,这在该病例或类似表现的发病机制中至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b139/12240087/ee731e8fb40f/gr1.jpg

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