Benayoun Bérénice A, Kochersberger Alison, Garrison Jennifer L
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA;
Molecular and Computational Biology Department, University of Southern California Dornsife College of Letters, Arts, and Sciences, Los Angeles, California 90089, USA.
Genes Dev. 2025 Aug 1;39(15-16):975-990. doi: 10.1101/gad.352732.125.
Ovarian aging is a critical yet understudied driver of systemic aging in female bodies, with profound implications for female health and longevity. Despite its significance, we still know little about ovarian aging and its systemic effects on aging trajectories. With new efforts over the past few years, interest in the field has been growing and there is momentum to address these questions. This review highlights the importance of leveraging modern tools and approaches to better understand ovarian aging and its impact on health span. Specifically, we believe it will be useful for both aging researchers looking to go into research on ovarian aging and reproductive researchers looking to adopt more modern toolkit. We focus on menopause-a key marker of ovarian aging-as a lens through which to examine the current state of the field, identify limitations in existing research, and outline goals for future progress. By emphasizing cutting-edge techniques and emerging models, we seek to illuminate new pathways for research that could lead to improved strategies for managing ovarian aging and enhancing overall female health.
卵巢衰老虽是女性身体系统性衰老的一个关键驱动因素，但却未得到充分研究，对女性健康和寿命有着深远影响。尽管其意义重大，但我们对卵巢衰老及其对衰老轨迹的系统性影响仍知之甚少。在过去几年的新努力下，该领域的关注度不断提高，解决这些问题的势头也日益增强。本综述强调了利用现代工具和方法来更好地理解卵巢衰老及其对健康寿命影响的重要性。具体而言，我们认为这对于希望开展卵巢衰老研究的衰老研究人员以及希望采用更现代工具包的生殖研究人员都将有所帮助。我们将绝经——卵巢衰老的一个关键标志——作为一个视角，通过它来审视该领域的现状，识别现有研究中的局限性，并概述未来进展的目标。通过强调前沿技术和新兴模型，我们旨在为研究开辟新途径，从而可能带来更好的管理卵巢衰老和增强女性整体健康的策略。
