Positive End-Expiratory Pressure and Atelectasis after Bronchial Blockade One-Lung Ventilation in Infants: A Randomized Controlled Study.

OBJECTIVE

This study aimed to evaluate the effect of positive end-expiratory pressure (PEEP) combined with 100% oxygen on atelectasis during emergence from anesthesia after one-lung ventilation (OLV) with a bronchial blocker in infants receiving thoracoscopic lobectomies.

DESIGN

This was a randomized controlled study.

SETTING

This study was performed in a teaching hospital.

PARTICIPANTS

Infants who received thoracoscopic lobectomies in our hospital from June 2024 to December 2024 were included in this study.

INTERVENTIONS

Sixty-nine infants (Group A) with bronchial blocker OLV thoracoscopic lobectomies received no PEEP but maintained intraoperative oxygen levels (FiO 0.6-0.8) after the removal of the bronchial blocker until extubation during emergence from anaesthesia. Another 69 infants who met the inclusion criteria and received PEEP of 5 to 6 cmHO, combined with 100% oxygen, after removal of the bronchial blocker until extubation during emergence from anesthesia, were included in Group B.

MEASUREMENTS

The inclusion criteria were as follows: (1) These infants were diagnosed with congenital cystic adenomatoid malformation and received bronchial blockade OLV thoracoscopic lobectomies; (2) American Society of Anesthesiologists (ASA) class I to II (ASA class I means a normal healthy patient; class II means a patient with mild systemic disease); and (3) age younger than 1 year. The exclusion criteria were as follows: (1) preoperative chest computed tomography or ultrasound suggestive of atelectasis; (2) intraoperative ventilation mode was changed to bilateral lung ventilation; (3) intraoperative FiO greater than 0.9; (4) cardiorespiratory dysfunction; (5) large cysts causing significant mediastinal shift or compressing cardiac chambers; and (6) declined to participate.

RESULTS

There were no significant differences in the preoperative general condition, perioperative hemodynamics, duration of operation, or length of postoperative hospital stay between the two groups (P > 0.05). There were no significant differences in the oxygenation index, alveolar-arterial oxygen differential pressure, or oxygen saturation (SpO) at T1 (the completion of surgery) (p > 0.05). At T2 (30 minutes after extubation), the oxygenation index and PaO level were greater, the alveolar-arterial oxygen differential pressure was lower, and the lowest postoperative SpO level within 30 minutes after extubation was better in Group B than in Group A (p < 0.05). The time from bronchial blocker removal to extubation was shorter in Group B than in Group A (p < 0.05). Compared with those of Group A, the proportions of patients with lung ultrasound scores of 3 (juxtapleural consolidation, large-sized consolidations and B-lines, white lung) and bedside chest radiography atelectasis scores of 3 (lobar atelectasis) in both lungs after extubation were lower in Group B (p < 0.05). The prevalence of hypoxemia (after extubation, SpO < 90%) was 46 (66.7%) in Group A and 14 (20.3%) in Group B, and the differences were statistically significant (p < 0.05). The duration of oxygen administration after extubation in Group B was shorter than that in Group A (p < 0.05). There was a statistically significant correlation between lung ultrasound scores and the chest radiographic atelectasis score in both groups (p < 0.05).

CONCLUSIONS

In one-lung ventilation using bronchial blockers performed during thoracoscopic lobectomies in infants, applying PEEP at 5 to 6 cmHO combined with 100% oxygen ventilation after the removal of the bronchial blocker until extubation was associated with improved oxygenation and did not appear to increase the risk of atelectasis during emergence from anesthesia. However, further studies are needed to evaluate the safety of this strategy.