Gao Sijia, Liu Jun, Wu Tixin, Li Shuang, Zhang Yongjun
School of Chemistry, Tiangong University, Tianjin 300387, China.
Cangzhou Institute of Tiangong University, Cangzhou, Hebei 061000, China.
Nano Lett. 2025 Jul 23;25(29):11291-11298. doi: 10.1021/acs.nanolett.5c02344. Epub 2025 Jul 10.
Due to its tunable degradation kinetics, broad-spectrum light absorption and biocompatibility, polydopamine (PDA) has emerged as a promising candidate for photothermal therapy. However, the photothermal conversion efficiency of PDA within the near-infrared spectral range is suboptimal. To address this issue, we synthesized PDA via a photo-Fenton reaction under neutral conditions. In this system, dopamine and Fe form bis-ligand complexes, enhancing iron content in the nanoparticles. Light irradiation accelerates electron transfer from ligands to Fe, speeding up PDA generation. The nanoparticles, named PDA-7.4-Fe-L NPs, exhibited a substantial improvement in photothermal conversion efficiency, reaching 52.24% under 808 nm laser irradiation. Notably, at a remarkably low concentration of 20 μg/mL, PDA-7.4-Fe-L NPs achieved exceptional antibacterial rates (>99.99%) against Gram-negative and Gram-positive within 10 min. The cytotoxicity results confirm that PDA-7.4-Fe-L NPs exhibit excellent biocompatibility. The remarkable antibacterial efficacy and biocompatibility of PDA-7.4-Fe-L NPs make it a potential antibacterial agent.
由于其可调节的降解动力学、广谱光吸收和生物相容性，聚多巴胺（PDA）已成为光热疗法的一个有前景的候选材料。然而，PDA在近红外光谱范围内的光热转换效率并不理想。为了解决这个问题，我们在中性条件下通过光芬顿反应合成了PDA。在这个体系中，多巴胺和铁形成双配体络合物，增加了纳米颗粒中的铁含量。光照射加速了电子从配体向铁的转移，加速了PDA的生成。这些纳米颗粒名为PDA-7.4-Fe-L NPs，其光热转换效率有了显著提高，在808 nm激光照射下达到了52.24%。值得注意的是，在低至20 μg/mL的浓度下，PDA-7.4-Fe-L NPs在10分钟内对革兰氏阴性菌和革兰氏阳性菌都实现了极高的抗菌率（>99.99%）。细胞毒性结果证实PDA-7.4-Fe-L NPs具有优异的生物相容性。PDA-7.4-Fe-L NPs卓越的抗菌功效和生物相容性使其成为一种潜在的抗菌剂。
