El-Khawaga Ahmed M, Elmaghraby Karim, Orlandini Maurizio
Department of Basic Medical Sciences, Faculty of Medicine, Galala University, Galala City, 43511, Suez, Egypt.
Department of Botany, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Sci Rep. 2025 Jul 10;15(1):24951. doi: 10.1038/s41598-025-08782-w.
To address the growing challenge of antibiotic resistance, magnetic nanoparticles were developed and characterized by providing an innovative solution. Zinc ferrite nanoparticles (ZnFe₂O₄ NPs) were synthesized using a chemical co-precipitation method, stabilized with citric acid (CA), and conjugated with amoxicillin (AX) to create ZnF-CA-AX nanocomposites. These nanoparticles were extensively characterized by their structural and optical properties. The antimicrobial activity of the nanocomposites was tested against gram-positive Staphylococcus aureus and gram-negative Escherichia coli, showing significant inhibition zones. Furthermore, the nanocomposites showed a high level of antibiofilm efficiency, and potential antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl. Collectively, these findings indicate that magnetic nanoparticles can enhance antibiotic effectiveness, offering new therapeutic avenues to combat resistant bacterial infections.
为应对日益严峻的抗生素耐药性挑战，人们开发了磁性纳米颗粒并对其进行表征，提供了一种创新解决方案。采用化学共沉淀法合成了锌铁氧体纳米颗粒（ZnFe₂O₄ NPs），用柠檬酸（CA）进行稳定化处理，并与阿莫西林（AX）共轭以制备ZnF-CA-AX纳米复合材料。这些纳米颗粒通过其结构和光学性质进行了广泛表征。测试了纳米复合材料对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的抗菌活性，显示出明显的抑菌圈。此外，纳米复合材料表现出高水平的抗生物膜效率，以及对1,1-二苯基-2-苦基肼的潜在抗氧化活性。总体而言，这些发现表明磁性纳米颗粒可以提高抗生素疗效，为对抗耐药细菌感染提供新的治疗途径。
