Duah Amoako, Asafu Adjaye Frempong, Asafu Adjaye Sedina, Agyei Nkansah Adwoa, Duah Francisca, Osei-Poku Foster, Ampofo Boobi Daniel
University of Ghana Medical Centre Medicine, Accra, Ghana.
Trust Hospital Medicine, Greater Accra, Accra, Ghana.
Rwanda J Med Health Sci. 2022 Apr 12;5(1):46-54. doi: 10.4314/rjmhs.v5i1.6. eCollection 2022 Apr.
In patients with liver cirrhosis, bacterial infections are common with high in-hospital mortality. In Ghana, bacterial infections in liver cirrhosis patients and their impact on in-patient mortality are generally unknown. This study was conducted to define the prevalence, predictors, and treatment outcomes of cirrhotic patients with bacterial infections admitted to a district hospital in Ghana.
Patients with liver cirrhosis hospitalized from 1st January, 2018 to 24th April, 2020 were consecutively recruited. The demographic data and clinical presentations of the patients were collected using standardized questionnaire. Full blood count, liver function test, renal function test, ascitic fluid analysis and culture, urinalysis and culture, hepatitis B surface antigen, anti-hepatitis C antibodies and abdominal ultrasound scans of the abdomen were conducted for all patients.
There were 110 (65.09%) males out of the 169 patients with a mean age of 47.10±12.88 years. The prevalence of infections was 42.01% (71/169). Out of 71 participants with infections, 59.15% (42/72) died. Fever, encephalopathy, high white cell count, Child-Pugh Class C and Blood urea nitrogen were independent predictors of bacterial infections.
Bacterial infection among the participants admitted to district hospital with liver cirrhosis was common with high in-hospital mortality.
在肝硬化患者中，细菌感染很常见，且院内死亡率很高。在加纳，肝硬化患者的细菌感染情况及其对住院死亡率的影响通常尚不明确。本研究旨在确定加纳一家地区医院收治的肝硬化合并细菌感染患者的患病率、预测因素及治疗结果。
连续招募2018年1月1日至2020年4月24日期间住院的肝硬化患者。使用标准化问卷收集患者的人口统计学数据和临床表现。对所有患者进行全血细胞计数、肝功能检查、肾功能检查、腹水分析和培养、尿液分析和培养、乙肝表面抗原、抗丙肝抗体检测以及腹部超声检查。
169例患者中有110例（65.09%）为男性，平均年龄为47.10±12.88岁。感染患病率为42.01%（71/169）。在71例感染患者中，59.15%（42/72）死亡。发热、肝性脑病、白细胞计数升高、Child-Pugh C级和血尿素氮是细菌感染的独立预测因素。
在该地区医院收治的肝硬化患者中，细菌感染很常见，且院内死亡率很高。
