Hou Xin-Zheng, Wu Qian, Yang Ying-Tian, Ye Xue-Jiao, Lv Qian-Yu, Yang Chen-Yan, Huang Ming-Yu, Wang Shi-Han
Department of Cardiovascular Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Public Health. 2025 Jun 26;13:1529506. doi: 10.3389/fpubh.2025.1529506. eCollection 2025.
Atherosclerotic cardiovascular disease (ASCVD) significantly threatens the health of the Chinese population. Understanding its epidemiological burden is vital for targeted interventions.
Using Global Burden of Diseases (GBD) 2021 data, we assessed Disability-Adjusted Life Years (DALYs), incidence, prevalence, and mortality of ischemic heart disease (IHD), stroke, and lower extremity peripheral artery disease (PAD) in China in 2021. Joinpoint regression analyzed trends from 1990 to 2021, and risk factor contributions to the disease burden were evaluated.
In 2021, age-standardized rates (ASRs) per 100,000 population for IHD (DALYs, incidence, prevalence, mortality) were 1856.5 (1548.7, 2159.8), 365.7 (293.3, 440.1), 3042.3 (2601.7, 3629.9), and 110.9 (92.4, 128.6), respectively, with males bearing a higher burden. For stroke, ASRs were 2648 (2253.4, 3076.9), 204.8 (181, 231.5), 1301.4 (1200.6, 1405.7), and 138 (116.7, 160.3), also higher in males. Lower extremity PAD showed ASRs of 8.4 (4.9, 14.3), 112.7 (97.8, 130.7), 1331.1 (1147.5, 1544.2), and 0.1 (0.1, 0.2), with a higher burden in females. Metabolic risks had the largest population-attributable fraction.
As of 2021, the epidemiological burden of IHD, stroke, and PAD in China remains substantial, with notable gender disparities. Metabolic risks significantly contribute to this burden.
动脉粥样硬化性心血管疾病（ASCVD）严重威胁中国人群的健康。了解其流行病学负担对于有针对性的干预措施至关重要。
利用全球疾病负担（GBD）2021年的数据，我们评估了2021年中国缺血性心脏病（IHD）、中风和下肢外周动脉疾病（PAD）的伤残调整生命年（DALYs）、发病率、患病率和死亡率。Joinpoint回归分析了1990年至2021年的趋势，并评估了风险因素对疾病负担的贡献。
2021年，每10万人口中IHD（DALYs、发病率、患病率、死亡率）的年龄标准化率（ASRs）分别为1856.5（1548.7，2159.8）、365.7（293.3，440.1）、3042.3（2601.7，3629.9）和110.9（92.4，128.6），男性负担较重。中风的ASRs分别为2648（2253.4，3076.9）、204.8（181，231.5）、1301.4（1200.6，1405.7）和138（116.7，160.3），男性也更高。下肢PAD的ASRs为8.4（4.9，14.3）、112.7（97.8，130.7）、1331.1（1147.5，1544.2）和0.1（0.1，0.2），女性负担较重。代谢风险在人群归因分数中占比最大。
截至2021年，中国IHD、中风和PAD的流行病学负担仍然很大，存在明显的性别差异。代谢风险对这一负担有显著贡献。
